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All Studies   Meta Analysis    Recent:   

Bromhexine for COVID-19: real-time meta analysis of 7 studies

Covid Analysis
May 2024  
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Statistically significant lower risk is seen for ventilation and ICU admission. 3 studies from 3 independent teams in 2 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 43% [-5‑69%] lower risk, without reaching statistical significance. Results are similar for peer-reviewed studies. Early treatment is more effective than late treatment. Currently all studies are RCTs.
2 RCTs with 304 patients have not reported results (up to 3 years late)1,2.
Bromhexine efficacy may vary depending on the degree of TMPRSS-dependent fusion for different variants3,4.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective.
All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., May 2024, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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