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Bromhexine for COVID-19: real-time meta analysis of 7 studies

Covid Analysis (Preprint) (meta analysis)
Covid Analysis, Bromhexine for COVID-19: real-time meta analysis of 7 studies, (Preprint) (meta analysis)
Jun 2023   Source   PDF  
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• Statistically significant improvements are seen for ventilation and ICU admission. 3 studies from 3 independent teams in 2 different countries show statistically significant improvements in isolation (not for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 43% [-5‑69%] improvement, without reaching statistical significance. Results are similar for peer-reviewed studies. Early treatment is more effective than late treatment. Currently all studies are RCTs.
• Currently there is limited data, with only 875 patients and only 13 control events for the most serious outcome in trials to date.
• Bromhexine efficacy may vary depending on the degree of TMPRSS-dependent fusion for different variants [Peacock, Willett].
• No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Only 57% of bromhexine studies show zero events with treatment.
• All data to reproduce this paper and sources are in the appendix.
Percentage improvement with bromhexine (more)
All studiesProphylaxisEarly treatmentStudies Patients Authors
All studies43% [-5‑69%]65% [-212‑96%]78% [30‑93%]* 7875 110
Randomized Controlled TrialsRCTs43% [-5‑69%]65% [-212‑96%]78% [30‑93%]* 7875 110
Mortality77% [-39‑96%]33% [-946‑96%]91% [-59‑99%] 3550 34
Cases62% [-11‑87%]62% [-11‑87%]- 2422 24
RCT mortality77% [-39‑96%]33% [-946‑96%]91% [-59‑99%] 3550 34
Covid Analysis et al., Jun 2023, preprint, 1 author.
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Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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