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0 0.5 1 1.5 2+ Moderate/severe case 95% Improvement Relative Risk Case 84% Iota-carrageenan  Chahla et al.  Prophylaxis  RCT Is prophylaxis with iota-carrageenan + ivermectin beneficial for COVID-19? RCT 234 patients in Argentina (October - December 2020) Fewer moderate/severe cases (p=0.0016) and cases (p=0.004) Chahla et al., American J. Therapeutics, Jan 2021 Favors carrageenan Favors control

Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina

Chahla et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001433, NCT04701710
Jan 2021  
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Prophylaxis RCT for ivermectin and iota-carrageenan in Argentina, 117 healthcare workers treated with ivermectin and iota-carrageenan, and 117 controls, showing significantly lower cases with treatment. There were no moderate/severe cases with treatment vs. 10 in the control group. There were 4 cases with treatment (all mild) vs. 25 for the control group.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
This study includes iota-carrageenan and ivermectin.
risk of moderate/severe case, 95.2% lower, RR 0.05, p = 0.002, treatment 0 of 117 (0.0%), control 10 of 117 (8.5%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), moderate/severe COVID-19.
risk of case, 84.0% lower, RR 0.16, p = 0.004, treatment 4 of 117 (3.4%), control 25 of 117 (21.4%), NNT 5.6, adjusted per study, odds ratio converted to relative risk, all cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chahla et al., 11 Jan 2021, Randomized Controlled Trial, Argentina, peer-reviewed, 11 authors, study period 15 October, 2020 - 31 December, 2020, this trial uses multiple treatments in the treatment arm (combined with ivermectin) - results of individual treatments may vary, trial NCT04701710 (history).
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Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina
tive effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
Rossana E. Chahla, MD, PhD 1 Luis Medina Ruiz, MD 2 Eugenia S. Ortega, MSc 3 Marcelo F. Morales, RN 4 Francisco Barreiro, MD 5 Alexia George, MD 5 Cesar Mancilla, RN 4 Sylvia D' Amato, RN 4 Guillermo Barrenechea, MSc 3 Daniel G. Goroso, PhD
Abd-Elsalam, Noor, Badawi, Clinical study evaluating the efficacy of ivermectin in COVID-19 treatment: A randomized controlled study
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