Insights from a multicenter nationwide cohort analysis in Japan on the association of underlying conditions and pharmacological interventions with COVID-19 disease severity

{ 'indexed': {'date-parts': [[2024, 9, 27]], 'date-time': '2024-09-27T12:40:23Z', 'timestamp': 1727440823282}, 'reference-count': 35, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 9, 27]], 'date-time': '2024-09-27T00:00:00Z', 'timestamp': 1727395200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by-nc-nd/4.0'}, { 'start': { 'date-parts': [[2024, 9, 27]], 'date-time': '2024-09-27T00:00:00Z', 'timestamp': 1727395200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by-nc-nd/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'DOI': '10.1186/s12982-024-00225-7', 'type': 'journal-article', 'created': {'date-parts': [[2024, 9, 27]], 'date-time': '2024-09-27T12:02:35Z', 'timestamp': 1727438555000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Insights from a multicenter nationwide cohort analysis in Japan on the association of underlying ' 'conditions and pharmacological interventions with COVID-19 disease severity', 'prefix': '10.1186', 'volume': '21', 'author': [ {'given': 'Kyoka', 'family': 'Sakamaki', 'sequence': 'first', 'affiliation': []}, {'given': 'Kiyoshi', 'family': 'Shibuya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wataru', 'family': 'Ando', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 9, 27]]}, 'reference': [ { 'issue': '7792', 'key': '225_CR1', 'doi-asserted-by': 'publisher', 'first-page': '607', 'DOI': '10.1038/d41586-020-00190-6', 'volume': '577', 'author': 'D Cyranoski', 'year': '2020', 'unstructured': 'Cyranoski D. This scientist hopes to test coronavirus drugs on animals ' 'in locked-down Wuhan. Nature. 2020;577(7792):607–607. ' 'https://doi.org/10.1038/d41586-020-00190-6.', 'journal-title': 'Nature'}, { 'key': '225_CR2', 'doi-asserted-by': 'publisher', 'first-page': '2158', 'DOI': '10.1007/s42399-020-00583-8', 'volume': '2', 'author': 'Y Ishikawa', 'year': '2020', 'unstructured': 'Ishikawa Y, Hifumi T, Otani N, Miyamichi R, Urashima M, Takeda S, et al. ' 'Relationship between the number of patients visiting emergency ' 'department and Tokyo health system’s capacity during early stages of the ' 'first wave of COVID-19. SN Compr Clin Med. 2020;2:2158–60. ' 'https://doi.org/10.1007/s42399-020-00583-8.', 'journal-title': 'SN Compr Clin Med'}, { 'key': '225_CR3', 'doi-asserted-by': 'publisher', 'first-page': '430', 'DOI': '10.3390/vaccines10030430', 'volume': '1', 'author': 'S Kodera', 'year': '2022', 'unstructured': 'Kodera S, Rashed EA, Hirata A. Estimation of real-world vaccination ' 'effectiveness of mRNA COVID-19 vaccines against delta and omicron ' 'variants in Japan. Vaccines (Basel). 2022;1:430. ' 'https://doi.org/10.3390/vaccines10030430.', 'journal-title': 'Vaccines (Basel)'}, { 'key': '225_CR4', 'doi-asserted-by': 'publisher', 'unstructured': 'Lee H, Chubachi S, Namkoong H, Asakura T, Tanaka H, Otake S, et al. ' 'Characteristics of hospitalized patients with COVID-19 during the first ' 'to fifth waves of infection: a report from the Japan COVID-19 Task ' 'Force. BMC Infect Dis. 2022;22. ' 'https://doi.org/10.1186/s12879-022-07927-w.', 'DOI': '10.1186/s12879-022-07927-w'}, { 'key': '225_CR5', 'doi-asserted-by': 'publisher', 'first-page': '100571', 'DOI': '10.1016/j.lanwpc.2022.100571', 'volume': '28', 'author': 'T Kayano', 'year': '2022', 'unstructured': 'Kayano T, Sasanami M, Kobayashi T, Ko YK, Otani K, Suzuki M, et al. ' 'Number of averted COVID-19 cases and deaths attributable to reduced risk ' 'in vaccinated individuals in Japan. Lancet Reg Health West Pac. ' '2022;28:100571. https://doi.org/10.1016/j.lanwpc.2022.100571.', 'journal-title': 'Lancet Reg Health West Pac'}, { 'key': '225_CR6', 'doi-asserted-by': 'publisher', 'first-page': '2779', 'DOI': '10.3390/ijerph20042779', 'volume': '20', 'author': 'Y Takahashi', 'year': '2023', 'unstructured': 'Takahashi Y, Tanaka H, Koga Y, Takiguchi S, Ogimoto S, Inaba S, et al. ' 'Change over time in the risk of death among Japanese COVID-19 cases ' 'caused by the Omicron variant depending on prevalence of sublineages. ' 'Int J Environ Res Public Health. 2023;20:2779. ' 'https://doi.org/10.3390/ijerph20042779.', 'journal-title': 'Int J Environ Res Public Health'}, { 'key': '225_CR7', 'unstructured': 'Behavioral risk factor surveillance system. 2022. ' 'https://www.cdc.gov/obesity/. Accessed June 30 2023.'}, { 'key': '225_CR8', 'unstructured': 'The Ministry of Health, Labour and Welfare in Japan. [Clinical ' 'Management of Patients with COVID-19 Version 9.0] in Japanese. 2022. ' 'https://www.mhlw.go.jp/. Accessed May 28 2023.'}, { 'key': '225_CR9', 'doi-asserted-by': 'publisher', 'first-page': '76', 'DOI': '10.1016/j.jiac.2020.09.022', 'volume': '27', 'author': 'T Hirashima', 'year': '2021', 'unstructured': 'Hirashima T, Arai T, Kitajima H, Tamura Y, Yamada T, Hashimoto S, et al. ' 'Factors significantly associated with COVID-19 severity in symptomatic ' 'patients: a retrospective single-center study. J Infect Chemother. ' '2021;27:76–82. https://doi.org/10.1016/j.jiac.2020.09.022.', 'journal-title': 'J Infect Chemother'}, { 'key': '225_CR10', 'doi-asserted-by': 'publisher', 'first-page': '487', 'DOI': '10.2188/jea.je20200519', 'volume': '31', 'author': 'Y Tsuchihashi', 'year': '2021', 'unstructured': 'Tsuchihashi Y, Arima Y, Takahashi T, Kanou K, Kobayashi Y, Sunagawa T, ' 'et al. Clinical characteristics and risk factors for severe outcomes of ' 'novel coronavirus infection, January–march 2020, Japan. J Epidemiol. ' '2021;31:487–94. https://doi.org/10.2188/jea.je20200519.', 'journal-title': 'J Epidemiol'}, { 'key': '225_CR11', 'doi-asserted-by': 'publisher', 'first-page': '1045', 'DOI': '10.1002/jmv.26389', 'volume': '93', 'author': 'RK Reddy', 'year': '2021', 'unstructured': 'Reddy RK, Charles WN, Sklavounos A, Dutt A, Seed PT, Khajuria A. The ' 'effect of smoking on COVID-19 severity: a systematic review and ' 'meta‐analysis. J Med Virol. 2021;93:1045–56. ' 'https://doi.org/10.1002/jmv.26389.', 'journal-title': 'J Med Virol'}, { 'key': '225_CR12', 'doi-asserted-by': 'publisher', 'first-page': 'e052777', 'DOI': '10.1136/bmjopen-2021-052777', 'volume': '11', 'author': 'Y Mahamat-Saleh', 'year': '2021', 'unstructured': 'Mahamat-Saleh Y, Fiolet T, Rebeaud ME, Mulot M, Guihur A, El Fatouhi D, ' 'et al. Diabetes, hypertension, body mass index, smoking and ' 'COVID-19-related mortality: a systematic review and meta-analysis of ' 'observational studies. BMJ Open. 2021;11:e052777. ' 'https://doi.org/10.1136/bmjopen-2021-052777.', 'journal-title': 'BMJ Open'}, { 'key': '225_CR13', 'doi-asserted-by': 'publisher', 'first-page': '817', 'DOI': '10.1001/jamapediatrics.2021.1050', 'volume': '175', 'author': 'J Villar', 'year': '2021', 'unstructured': 'Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A, et al. ' 'Maternal and neonatal morbidity and mortality among pregnant women with ' 'and without COVID-19 infection: the INTERCOVID multinational cohort ' 'study. JAMA Pediatr. 2021;175:817. ' 'https://doi.org/10.1001/jamapediatrics.2021.1050.', 'journal-title': 'JAMA Pediatr'}, { 'key': '225_CR14', 'doi-asserted-by': 'publisher', 'first-page': '1078', 'DOI': '10.1093/ije/dyab254', 'volume': '51', 'author': 'Y Matsushita', 'year': '2022', 'unstructured': 'Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, et ' 'al. Smoking and severe illness in hospitalized COVID-19 patients in ' 'Japan. Int J Epidemiol. 2022;51:1078–87. ' 'https://doi.org/10.1093/ije/dyab254.', 'journal-title': 'Int J Epidemiol'}, { 'key': '225_CR15', 'doi-asserted-by': 'publisher', 'first-page': '74', 'DOI': '10.1016/j.ajog.2021.12.032', 'volume': '227', 'author': 'B Eskenazi', 'year': '2022', 'unstructured': 'Eskenazi B, Rauch S, Iurlaro E, Gunier RB, Rego A, Gravett MG, et al. ' 'Diabetes mellitus, maternal adiposity, and insulin-dependent gestational ' 'diabetes are associated with COVID-19 in pregnancy: the INTERCOVID ' 'study. Am J Obstet Gynecol. 2022;227:74. .e1-74.e16.', 'journal-title': 'Am J Obstet Gynecol'}, { 'key': '225_CR16', 'unstructured': 'The ministry of internal affairs and communications in Japan. ' 'Visualizing the data: information on COVID-19 infection. ' 'https://covid19.mhlw.go.jp/extensions/public/en/index.html; Accessed ' 'July 2 2024.'}, { 'key': '225_CR17', 'doi-asserted-by': 'publisher', 'unstructured': 'Pietrobon AJ, Teixeira FME, Sato MN. Immunosenescence and inflammaging: ' 'risk factors of severe COVID-19 in older people. Front Immunol. 2020;11. ' 'https://doi.org/10.3389/fimmu.2020.579220.', 'DOI': '10.3389/fimmu.2020.579220'}, { 'key': '225_CR18', 'doi-asserted-by': 'publisher', 'unstructured': 'Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, ' 'Wedderburn LR, et al. Male sex identified by global COVID-19 ' 'meta-analysis as a risk factor for death and ITU admission. Nat Commun. ' '2020;11. https://doi.org/10.1038/s41467-020-19741-6.', 'DOI': '10.1038/s41467-020-19741-6'}, { 'key': '225_CR19', 'doi-asserted-by': 'publisher', 'first-page': 'e0276781', 'DOI': '10.1371/journal.pone.0276781', 'volume': '17', 'author': 'H Pavey', 'year': '2022', 'unstructured': 'Pavey H, Kulkarni S, Wood A, Ben-Shlomo Y, Sever P, McEniery C, et al. ' 'Primary hypertension, anti-hypertensive medications and the risk of ' 'severe COVID-19 in UK Biobank. PLoS ONE. 2022;17:e0276781. ' 'https://doi.org/10.1371/journal.pone.0276781.', 'journal-title': 'PLoS ONE'}, { 'key': '225_CR20', 'doi-asserted-by': 'publisher', 'first-page': '2002108', 'DOI': '10.1183/13993003.02108-2020', 'volume': '56', 'author': 'JM Leung', 'year': '2020', 'unstructured': 'Leung JM, Niikura M, Yang CWT, Sin DD. COVID-19 and COPD. Eur Respir J. ' '2020;56:2002108. https://doi.org/10.1183/13993003.02108-2020.', 'journal-title': 'Eur Respir J'}, { 'key': '225_CR21', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/ehjqcco/qcab029', 'author': 'SL Harrison', 'year': '2021', 'unstructured': 'Harrison SL, Buckley BJR, Rivera-Caravaca JM, Zhang J, Lip GYH. ' 'Cardiovascular risk factors, cardiovascular disease, and COVID-19: an ' 'umbrella review of systematic reviews. Eur Heart J Qual Care Clin ' 'Outcomes. 2021. https://doi.org/10.1093/ehjqcco/qcab029.', 'journal-title': 'Eur Heart J Qual Care Clin Outcomes'}, { 'key': '225_CR22', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1007/s10741-020-10008-2', 'volume': '26', 'author': 'F Bader', 'year': '2021', 'unstructured': 'Bader F, Manla Y, Atallah B, Starling RC. Heart failure and COVID-19. ' 'Heart Fail Rev. 2021;26:1–10. ' 'https://doi.org/10.1007/s10741-020-10008-2.', 'journal-title': 'Heart Fail Rev'}, { 'key': '225_CR23', 'doi-asserted-by': 'publisher', 'first-page': '2508', 'DOI': '10.3390/cells9112508', 'volume': '9', 'author': 'A Magadum', 'year': '2020', 'unstructured': 'Magadum A, Kishore R. Cardiovascular manifestations of COVID-19 ' 'infection. Cells. 2020;9:2508. https://doi.org/10.3390/cells9112508.', 'journal-title': 'Cells'}, { 'key': '225_CR24', 'doi-asserted-by': 'publisher', 'unstructured': 'Mehboob R, von Kries JP, Ehsan K, Almansouri M, Bamaga AK. Role of ' 'endothelial cells and angiotensin converting enzyme-II in COVID-19 and ' 'brain damages post-infection. Front Neurol. 2023;14. ' 'https://doi.org/10.3389/fneur.2023.1210194.', 'DOI': '10.3389/fneur.2023.1210194'}, { 'key': '225_CR25', 'doi-asserted-by': 'publisher', 'first-page': '833', 'DOI': '10.1161/hypertensionaha.120.16314', 'volume': '77', 'author': 'L Semenzato', 'year': '2021', 'unstructured': 'Semenzato L, Botton J, Drouin J, Baricault B, Vabre C, Cuenot F, et al. ' 'Antihypertensive drugs and COVID-19 risk: a cohort study of 2 million ' 'hypertensive patients. Hypertension. 2021;77:833–42. ' 'https://doi.org/10.1161/hypertensionaha.120.16314.', 'journal-title': 'Hypertension'}, { 'key': '225_CR26', 'doi-asserted-by': 'publisher', 'first-page': '575', 'DOI': '10.1007/s00592-020-01654-x', 'volume': '58', 'author': 'X Lu', 'year': '2021', 'unstructured': 'Lu X, Cui Z, Pan F, Li L, Li L, Liang B, et al. Glycemic status affects ' 'the severity of coronavirus disease 2019 in patients with diabetes ' 'mellitus: an observational study of CT radiological manifestations using ' 'an artificial intelligence algorithm. Acta Diabetol. 2021;58:575–86. ' 'https://doi.org/10.1007/s00592-020-01654-x.', 'journal-title': 'Acta Diabetol'}, { 'key': '225_CR27', 'doi-asserted-by': 'publisher', 'first-page': '1068', 'DOI': '10.1016/j.cmet.2020.04.021', 'volume': '31', 'author': 'L Zhu', 'year': '2020', 'unstructured': 'Zhu L, She Z-G, Cheng X, Qin J-J, Zhang X-J, Cai J, et al. Association ' 'of blood glucose control and outcomes in patients with COVID-19 and ' 'pre-existing type 2 diabetes. Cell Metab. 2020;31:1068–e10773. ' 'https://doi.org/10.1016/j.cmet.2020.04.021.', 'journal-title': 'Cell Metab'}, { 'key': '225_CR28', 'doi-asserted-by': 'publisher', 'first-page': '2030', 'DOI': '10.3390/jcm9072030', 'volume': '9', 'author': 'B Fernandez-Fernandez', 'year': '2020', 'unstructured': 'Fernandez-Fernandez B, D’Marco L, Górriz JL, Jacobs-Cachá C, Kanbay M, ' 'Luis-Lima S, et al. Exploring sodium glucose co-transporter-2 (SGLT2) ' 'inhibitors for organ protection in COVID-19. J Clin Med. 2020;9:2030. ' 'https://doi.org/10.3390/jcm9072030.', 'journal-title': 'J Clin Med'}, { 'key': '225_CR29', 'doi-asserted-by': 'publisher', 'first-page': '843', 'DOI': '10.1016/s0140-6736(21)01744-x', 'volume': '398', 'author': 'L-M Yu', 'year': '2021', 'unstructured': 'Yu L-M, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, et al. ' 'Inhaled budesonide for COVID-19 in people at high risk of complications ' 'in the community in the UK (PRINCIPLE): a randomised, controlled, ' 'open-label, adaptive platform trial. Lancet. 2021;398:843–55. ' 'https://doi.org/10.1016/s0140-6736(21)01744-x.', 'journal-title': 'Lancet'}, { 'key': '225_CR30', 'doi-asserted-by': 'publisher', 'first-page': '1065', 'DOI': '10.1016/s2213-2600(20)30447-1', 'volume': '8', 'author': 'D Singh', 'year': '2020', 'unstructured': 'Singh D, Halpin DMG. Inhaled corticosteroids and COVID-19-related ' 'mortality: confounding or clarifying? Lancet Respir Med. 2020;8:1065–6. ' 'https://doi.org/10.1016/s2213-2600(20)30447-1.', 'journal-title': 'Lancet Respir Med'}, { 'key': '225_CR31', 'doi-asserted-by': 'publisher', 'first-page': 'e0260451', 'DOI': '10.1371/journal.pone.0260451', 'volume': '16', 'author': 'M Hirayama', 'year': '2021', 'unstructured': 'Hirayama M, Nishiwaki H, Hamaguchi T, Ito M, Ueyama J, Maeda T, et al. ' 'Intestinal Collinsella may mitigate infection and exacerbation of ' 'COVID-19 by producing ursodeoxycholate. PLoS ONE. 2021;16:e0260451. ' 'https://doi.org/10.1371/journal.pone.0260451.', 'journal-title': 'PLoS ONE'}, { 'key': '225_CR32', 'doi-asserted-by': 'publisher', 'first-page': '35', 'DOI': '10.1265/ehpm.23-00061', 'volume': '28', 'author': 'K Tomioka', 'year': '2023', 'unstructured': 'Tomioka K, Uno K, Yamada M. Association between vaccination status and ' 'severe health consequences among community-dwelling COVID-19 patients ' 'during Omicron BA.1/BA.2 and BA.5-predominant periods in Japan. Environ ' 'Health Prev Med. 2023;28:35–35. https://doi.org/10.1265/ehpm.23-00061.', 'journal-title': 'Environ Health Prev Med'}, { 'key': '225_CR33', 'doi-asserted-by': 'publisher', 'first-page': '523', 'DOI': '10.2188/jea.je20200138', 'volume': '31', 'author': 'T Ikeda', 'year': '2021', 'unstructured': 'Ikeda T, Cable N, Saito M, Koyama S, Tsuji T, Noguchi T, et al. ' 'Association between social isolation and smoking in Japan and England. J ' 'Epidemiol. 2021;31:523–9. https://doi.org/10.2188/jea.je20200138.', 'journal-title': 'J Epidemiol'}, { 'key': '225_CR34', 'doi-asserted-by': 'publisher', 'first-page': '57040', 'DOI': '10.1007/s11356-022-21461-x', 'volume': '29', 'author': 'P Mal', 'year': '2022', 'unstructured': 'Mal P, Mukherjee T, Upadhyay AK, Mohanty S, Pattnaik AK. Connecting the ' 'dots between inflammatory cascades of obesity and COVID-19 in light of ' 'mortal consequences—a review. Environ Sci Pollut Res Int. ' '2022;29:57040–53. https://doi.org/10.1007/s11356-022-21461-x.', 'journal-title': 'Environ Sci Pollut Res Int'}, { 'key': '225_CR35', 'doi-asserted-by': 'publisher', 'unstructured': 'Kazemi SN, Hajikhani B, Didar H, Hosseini SS, Haddadi S, Khalili F, et ' 'al. COVID-19 and cause of pregnancy loss during the pandemic: a ' 'systematic review. PLoS ONE. 2021;1694. ' 'https://doi.org/10.1371/journal.pone.0255994.', 'DOI': '10.1371/journal.pone.0255994'}], 'container-title': 'Discover Public Health', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12982-024-00225-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s12982-024-00225-7/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12982-024-00225-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 9, 27]], 'date-time': '2024-09-27T12:02:40Z', 'timestamp': 1727438560000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://ete-online.biomedcentral.com/articles/10.1186/s12982-024-00225-7'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 9, 27]]}, 'references-count': 35, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'alternative-id': ['225'], 'URL': 'http://dx.doi.org/10.1186/s12982-024-00225-7', 'relation': {}, 'ISSN': ['3005-0774'], 'subject': [], 'container-title-short': 'Discov Public Health', 'published': {'date-parts': [[2024, 9, 27]]}, 'assertion': [ { 'value': '22 February 2024', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '13 September 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '27 September 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'This study was approved by the Ethical Committee of Kitasato University Medical ' 'Center (No. 2022028). The ethics committee confirmed that all methods were ' 'performed in accordance with the Ethical Guidelines for Medical and Health ' 'Research Involving Human Subjects in Japan and relevant regulations.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'This study utilized anonymized data from a retrospective analysis, and the need ' 'for informed consent from the subjects was waived by the Kitasato University ' 'Hospital Ethics Committee.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to participate'}}, { 'value': 'Not applicable.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to publish'}}, { 'value': 'The authors declare no competing interests.', 'order': 5, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '112'}