Cannabidiol and Its Effects on Patients with COVID-19 Infection

Kuntzman et al., Israel Medical Association Journal, 27:2, Feb 2025
Mortality 77% improvement lower risk ← → higher risk ICU admission 57% Hospitalization time 22% Cannabidiol  Kuntzman et al.  LATE TREATMENT RCT Is late treatment with cannabidiol beneficial for COVID-19? Double-blind RCT 10 patients in Israel Lower mortality with cannabidiol (not stat. sig., p=0.3) c19early.org Kuntzman et al., Israel Medical Associ.., Feb 2025 0 0.5 1 1.5 2+ RR
RCT 10 hospitalized COVID-19 patients showing potential benefit with sublingual cannabidiol (CBD) oil. There was only 7 patients in the treatment arm and 3 in the placebo group. CBD-treated patients showed a trends toward lower inflammatory cytokine levels including IL-6, IL-10, TNF-α, and C-reactive protein, though none reached statistical significance.
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risk of death, 76.9% lower, RR 0.23, p = 0.30, treatment 0 of 7 (0.0%), control 1 of 3 (33.3%), NNT 3.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 57.1% lower, RR 0.43, p = 1.00, treatment 1 of 7 (14.3%), control 1 of 3 (33.3%), NNT 5.2.
hospitalization time, 22.4% lower, relative time 0.78, p = 0.61, treatment mean 5.9 (±5.13) n=7, control mean 7.6 (±3.0) n=3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kuntzman et al., 28 Feb 2025, Double Blind Randomized Controlled Trial, Israel, peer-reviewed, 3 authors.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org September 2026 Israel Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines USA Brazil France Italy Canada Pakistan Spain Vietnam Japan Nepal Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Saudi Arabia Algeria Morocco Yemen Poland Uzbekistan India China Venezuela DR Congo Madagascar Thailand Uganda Egypt Nigeria Taiwan Fiji Zambia Bosnia-Herzegovina Dominican Republic Bolivia Côte d'Ivoire Eritrea Togo Bulgaria Greece Slovakia Iceland New Zealand Mongolia Czechia Belarus Haiti Hong Kong Qatar Panama Serbia Israel favored high-profit treatments.The average efficacy of treatments was moderate.High-cost protocols reduce early treatment, andforgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org September 2026 Israel Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines USA Brazil France Italy Canada Pakistan Spain Vietnam Japan Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Algeria Morocco Yemen Poland Uzbekistan India China Venezuela DR Congo Madagascar Thailand Uganda Egypt Taiwan Fiji Zambia Dominican Rep. Bolivia Côte d'Ivoire Eritrea Togo Sri Lanka Bulgaria Greece Slovakia New Zealand Czechia Belarus Qatar Panama Serbia Israel favored high-profit treatments.The average efficacy was moderate.High-cost protocols reduce early treatment,and forgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
Late treatment
is less effective
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