Development and Optimization of Lyophilized Dry Emulsion Tablet for Improved Oral Delivery of Ivermectin

Madawi et al., Journal of Drug Delivery Science and Technology, doi:10.1016/j.jddst.2025.106941, Apr 2025

Ivermectin for COVID-19

4th treatment shown to reduce risk in August 2020, now with p < 0.0000000001 from 106 studies, recognized in 24 countries.

No treatment is 100% effective.
Protocols combine treatments.

In vitro and rabbit study showing that rapidly disintegrating lyophilized dry-emulsion tablets (IVM-LDET) markedly improve oral ivermectin delivery. Authors applied a quality-by-design approach to oil-in-water emulsions (sweet almond oil + Span 80/Tween 80), then freeze-dried them into tablets that disintegrated in seconds, boosting ivermectin solubility 600-fold and achieving near-complete dissolution within ten minutes. Pharmacokinetic testing in rabbits (single 6 mg-equivalent dose) showed a 30% rise in Cmax, a 30% rise in AUC0-∞, and a 4h reduction in Tmax versus the commercial tablet, suggesting higher and faster systemic exposure that could permit lower dosing and better tolerability for COVID-19 treatment.
8 studies investigate novel formulations of ivermectin for improved efficacy1-8
Madawi et al., 18 Apr 2025, peer-reviewed, 6 authors.
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