Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
et al., New England Journal of Medicine, doi:10.1056/NEJMoa2030340, EMPACTA, NCT04372186, Jan 2021
RCT 377 hospitalized COVID-19 patients with pneumonia showing that tocilizumab significantly reduced mechanical ventilation or death by day 28, however there was no difference in mortality alone.
|
risk of death, 21.5% higher, RR 1.22, p = 0.72, treatment 26 of 249 (10.4%), control 11 of 128 (8.6%), day 28.
|
|
risk of death/intubation, 44.0% lower, HR 0.56, p = 0.03, treatment 249, control 128, day 28.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Salama et al., 7 Jan 2021, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, mean age 55.9, 20 authors, trial NCT04372186 (history) (EMPACTA).
Contact: mohan.shalini@gene.com.
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
New England Journal of Medicine, doi:10.1056/nejmoa2030340
interleukin-6 receptor antibody tocilizumab in patients from these populations who are hospitalized with Covid-19 pneumonia are unclear.
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Late treatment
is less effective
is less effective
