All Studies Meta Analysis Recent:

Safety and Efficacy of Drugs Given Off-label for COVID-19

Fernandez-Tresguerres et al., NCT05596617, NCT05596617

Mar 2022

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Melatonin for COVID-19

11th treatment shown to reduce risk in December 2020

^*, now with p = 0.0000002 from 18 studies.

Lower risk for mortality, ventilation, and recovery.

No treatment is 100% effective. Protocols combine treatments. ^* >10% efficacy, ≥3 studies.

4,500+ studies for 81 treatments. c19early.org

335 patient melatonin late treatment study with results not reported over 2 years after completion.

3 melatonin RCTs have results missing long after expected1-3
The trials report a total of 268 patients, with 2 trials having actual enrollment of 168, and the other estimated.

Important missing comments or errors? Let us know.

1. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444.clinicaltrials.gov.

2. Piovezan et al., Adjuvant Therapeutic Effects of Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19, NCT04470297, clinicaltrials.gov/study/NCT04470297.clinicaltrials.gov.

3. Rodríguez-Rubio et al., A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial, Trials, doi:10.1186/s13063-020-04632-4.biomedcentral.com, doi.org.

Fernandez-Tresguerres et al., 31 Mar 2022, Spain, trial NCT05596617 (history).

This Paper Melatonin All

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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