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Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA COVID-19 PROJECT

Cordero et al., NCT04695704, E-SPERANZA, NCT04695704

Aug 2023

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Montelukast

29th treatment shown to reduce risk in November 2021

^*, now with p = 0.0041 from 9 studies.

Lower risk for hospitalization and cases.

No treatment is 100% effective. Protocols combine treatments. ^* >10% efficacy, ≥3 studies.

5,000+ studies for 104 treatments. c19early.org

Estimated 284 patient montelukast late treatment RCT with results not reported over 1 year after estimated completion.

2 montelukast RCTs have results missing long after expected1,2
The trials report an estimated total of 664 patients.

Important missing comments or errors? Let us know.

1. Cordero et al., Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA COVID-19 PROJECT, NCT04695704, clinicaltrials.gov/study/NCT04695704.clinicaltrials.gov.

2. Durdagi et al., A National, Multi-Center, Open-Label, Three-Arm, Phase II Study to Investigate the Effect of Montelukast Between Emergency Room Visits and Hospitalizations in COVID-19 Pneumonia in Comparison With Standard Treatment, NCT04718285, clinicaltrials.gov/study/NCT04718285.clinicaltrials.gov.

Cordero et al., 31 Aug 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Spain, trial NCT04695704 (history) (E-SPERANZA). Contact: franmcor@hotmail.com, rmorros@idiapjgol.org.

This Paper Montelukast All

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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