A manual of medical treatment or clinical therapeutics

Yeo, B., 1901, Jan 1901

HCQ for COVID-19

1st treatment shown to reduce risk in March 2020, now with p < 0.0000000001 from 426 studies, used in 59 countries.

No treatment is 100% effective.
Protocols combine treatments.

Quinine is refered to as "the remedy that is most deserving of confidence in the treatment of influenza".
Yeo et al., 1 Jan 1901, peer-reviewed, 1 author.