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'abstract': '<jats:title>Abstract</jats:title>\n'
' <jats:p>Many mechanisms are thought to play a role in the pathogenesis of the '
'COVID-19 pandemic, which started in 2019 and affected the whole world. It has been claimed '
'that a deficiency in the immune system can significantly affect the severity of COVID-19 '
'disease. It is important that the levels of essential elements and vitamin D are at certain '
'levels for the healthy functioning of the immune system. Therefore, in this study, it was '
'aimed to evaluate immunotoxicity biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin '
'(IL)-10, interferon (IFN)-γ, monocyte chemotactic protein-1 (MCP-1)), vitamin D, and '
'essential element levels in COVID-19 patients in Turkey. According to the results of the '
'study, it was found that the magnesium (Mg), zinc (Zn), and selenium (Se) levels decreased as '
'the severity of the disease worsened, while the iron (Fe), and copper (Cu) levels were '
'similar to the mild group and the control group, and the levels decreased as the disease '
'worsened. It has also been found that vitamin D levels decrease as the severity of the '
'disease worsens. Compared to the control group, TNF-α, MCP-1, and IFN-γ levels were found to '
'decrease as the severity of the disease worsened. Also, it was observed that there was a '
'significant relationship between essential metal levels and disease progression in most of '
'the patient groups.</jats:p>',
'DOI': '10.1093/toxres/tfae177',
'type': 'journal-article',
'created': { 'date-parts': [[2024, 10, 15]],
'date-time': '2024-10-15T16:12:12Z',
'timestamp': 1729008732000},
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'title': 'Effects of Immunotoxicity biomarkers, essential elements and vitamin D levels on the severity '
'levels of COVID-19 disease in Turkey',
'prefix': '10.1093',
'volume': '13',
'author': [ { 'ORCID': 'http://orcid.org/0000-0002-4875-2266',
'authenticated-orcid': False,
'given': 'Jülide',
'family': 'Secerlı',
'sequence': 'first',
'affiliation': [ { 'name': 'Department of Pharmaceutical Toxicology, University of Health '
'Sciences Turkey, Gülhane Faculty of Pharmacy , 06018 Ankara ,',
'place': ['Türkiye']}]},
{ 'ORCID': 'http://orcid.org/0000-0001-9469-5066',
'authenticated-orcid': False,
'given': 'Serdar',
'family': 'Çetinkaya',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Pharmaceutical Toxicology, University of Health '
'Sciences Turkey, Gülhane Faculty of Pharmacy , 06018 Ankara ,',
'place': ['Türkiye']}]},
{ 'ORCID': 'http://orcid.org/0000-0003-3752-1777',
'authenticated-orcid': False,
'given': 'İlknur Sıla',
'family': 'Leblebici',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Pharmaceutical Toxicology, University of Health '
'Sciences Turkey, Gülhane Faculty of Pharmacy , 06018 Ankara ,',
'place': ['Türkiye']}]},
{ 'ORCID': 'http://orcid.org/0009-0002-6781-5960',
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'given': 'Latif Alperen',
'family': 'Özdemir',
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'affiliation': [ { 'name': 'Department of Chest Diseases, University of Health Sciences '
'Turkey, Gülhane Research and Training Hospital , 06018 Ankara ,',
'place': ['Türkiye']}]},
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'given': 'Çiğdem',
'family': 'Yücel',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Pharmaceutical Biochemistry, University of Health '
'Sciences Turkey, Gülhane Faculty of Pharmacy , 06018 Ankara ,',
'place': ['Türkiye']}]},
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'authenticated-orcid': False,
'given': 'Eda',
'family': 'Karaismailoğlu',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Biostatistics, University of Health Sciences '
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'place': ['Türkiye']}]},
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'authenticated-orcid': False,
'given': 'Umut',
'family': 'Kara',
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'affiliation': [ { 'name': 'General Intensive Care Unit, Special Acıbadem Ataşehir Hospital '
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'place': ['Türkiye']}]},
{ 'ORCID': 'http://orcid.org/0000-0003-1868-0617',
'authenticated-orcid': False,
'given': 'Aydan',
'family': 'Özcan',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Sports Medicine, University of Health Sciences '
'Turkey, Gülhane Faculty of Medicine , 06018 Ankara ,',
'place': ['Türkiye']}]},
{ 'ORCID': 'http://orcid.org/0000-0002-3789-7769',
'authenticated-orcid': False,
'given': 'Nesrin',
'family': 'Öcal',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Chest Diseases, University of Health Sciences '
'Turkey, Gülhane Research and Training Hospital , 06018 Ankara ,',
'place': ['Türkiye']}]},
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'given': 'Yakup',
'family': 'Arslan',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Chest Diseases, University of Health Sciences '
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'given': 'Serkan',
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'affiliation': [ { 'name': 'General Intensive Care Unit, Special Acıbadem Ataşehir Hospital '
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'given': 'Onur',
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'affiliation': [ { 'name': 'Department of Pharmaceutical Toxicology, University of Health '
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'given': 'Merve Güdül',
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'affiliation': [ { 'name': 'Department of Pharmaceutical Toxicology, University of Health '
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'first-page': '265',
'DOI': '10.1038/s41586-020-2008-3',
'article-title': 'A new coronavirus associated with human respiratory disease in China',
'volume': '579',
'author': 'Wu',
'year': '2020',
'journal-title': 'Nature'},
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'key': '2024102103415428900_ref2',
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'first-page': '1',
'DOI': '10.1186/s12967-020-02520-8',
'article-title': 'Pathophysiology and treatment strategies for COVID-19',
'volume': '18',
'author': 'Kumar',
'year': '2020',
'journal-title': 'J Transl Med'},
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'DOI': '10.3389/FIMMU.2023.1125246',
'article-title': 'The development of COVID-19 treatment',
'volume': '14',
'author': 'Yuan',
'year': '2023',
'journal-title': 'Front Immunol'},
{ 'key': '2024102103415428900_ref4',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.phrs.2020.105051',
'article-title': 'Targeting inflammation and cytokine storm in COVID-19',
'volume': '159',
'author': 'Huang',
'year': '2020',
'journal-title': 'Pharmacol Res'},
{ 'issue': '1',
'key': '2024102103415428900_ref5',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1038/s41392-020-00243-2',
'article-title': 'COVID-19: immunopathogenesis and Immunotherapeutics',
'volume': '5',
'author': 'Yang',
'year': '2020',
'journal-title': 'Signal Transduction Targeted Ther'},
{ 'issue': '2',
'key': '2024102103415428900_ref6',
'first-page': '188',
'article-title': 'Current concepts in the diagnosis and management of cytokine release '
'syndrome',
'volume': '124',
'author': 'Lee',
'year': '2014',
'journal-title': 'J Am Soc Hematol'},
{ 'issue': '7',
'key': '2024102103415428900_ref7',
'doi-asserted-by': 'crossref',
'first-page': '2074',
'DOI': '10.3390/nu12072074',
'article-title': 'Relevance of essential trace elements in nutrition and drinking water '
'for human health and autoimmune disease risk',
'volume': '12',
'author': 'Cannas',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'issue': '4',
'key': '2024102103415428900_ref8',
'doi-asserted-by': 'crossref',
'first-page': '416',
'DOI': '10.1007/s12291-021-00961-6',
'article-title': 'Trace elements as Immunoregulators in SARS-CoV-2 and other viral '
'infections',
'volume': '1-11',
'author': 'Dharmalingam',
'year': '2021',
'journal-title': 'Indian J Clin Biochem'},
{ 'issue': '1',
'key': '2024102103415428900_ref9',
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'first-page': '90',
'DOI': '10.1007/s12016-022-08921-5',
'article-title': 'Risk and protective factors for COVID-19 morbidity, severity, and '
'mortality',
'volume': '64',
'author': 'Zhang',
'year': '2023',
'journal-title': 'Clin Rev Allergy Immunol'},
{ 'issue': '2',
'key': '2024102103415428900_ref10',
'doi-asserted-by': 'crossref',
'first-page': '356',
'DOI': '10.1006/cimm.1993.1245',
'article-title': 'Impaired bone marrow-derived macrophage differentiation in vitamin D '
'deficiency',
'volume': '151',
'author': 'Abu-Amer',
'year': '1993',
'journal-title': 'Cell Immunol'},
{ 'issue': '8',
'key': '2024102103415428900_ref11',
'doi-asserted-by': 'crossref',
'first-page': '2419',
'DOI': '10.3390/ijms19082419',
'article-title': 'Vitamin D and influenza—prevention or therapy?',
'volume': '19',
'author': 'Gruber-Bzura',
'year': '2018',
'journal-title': 'Int J Mol Sci'},
{ 'issue': '1',
'key': '2024102103415428900_ref12',
'doi-asserted-by': 'crossref',
'first-page': '3312',
'DOI': '10.1038/s41598-017-03474-6',
'article-title': 'Chronic vitamin D deficiency induces lung fibrosis through activation '
'of the renin-angiotensin system',
'volume': '7',
'author': 'Shi',
'year': '2017',
'journal-title': 'Sci Rep'},
{ 'issue': '6',
'key': '2024102103415428900_ref13',
'doi-asserted-by': 'crossref',
'first-page': '1129',
'DOI': '10.1017/S0950268806007175',
'article-title': 'Epidemic influenza and vitamin D',
'volume': '134',
'author': 'Cannell',
'year': '2006',
'journal-title': 'Epidemiol Infect'},
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'doi-asserted-by': 'crossref',
'first-page': 'i6583',
'DOI': '10.1136/bmj.i6583',
'article-title': 'Vitamin D supplementation to prevent acute respiratory tract '
'infections: systematic review and meta-analysis of individual '
'participant data. The',
'volume': '356',
'author': 'Martineau',
'year': '2017',
'journal-title': 'BMJ'},
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'key': '2024102103415428900_ref15',
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'first-page': '1195',
'DOI': '10.1007/s40520-020-01570-8',
'article-title': 'The role of vitamin D in the prevention of coronavirus disease 2019 '
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'volume': '32',
'author': 'Ilie',
'year': '2020',
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'key': '2024102103415428900_ref16',
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'first-page': 'e2019722',
'DOI': '10.1001/jamanetworkopen.2020.19722',
'article-title': 'Association of Vitamin D Status and Other Clinical Characteristics with '
'COVID-19 test results',
'volume': '3',
'author': 'Meltzer',
'year': '2020',
'journal-title': 'JAMA Netw Open'},
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'doi-asserted-by': 'crossref',
'first-page': '117808',
'DOI': '10.1016/j.lfs.2020.117808',
'article-title': 'Lungs as target of COVID-19 infection: protective common molecular '
'mechanisms of vitamin D and melatonin as a new potential synergistic '
'treatment',
'volume': '254',
'author': 'Giménez',
'year': '2020',
'journal-title': 'Life Sci'},
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'key': '2024102103415428900_ref18',
'doi-asserted-by': 'crossref',
'first-page': '724',
'DOI': '10.1080/07315724.2020.1826005',
'article-title': 'Does serum vitamin D level affect COVID-19 infection and its '
'severity?-a case-control study',
'volume': '40',
'author': 'Ye',
'year': '2021',
'journal-title': 'J Am Coll Nutr'},
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'key': '2024102103415428900_ref19',
'doi-asserted-by': 'crossref',
'first-page': '3051',
'DOI': '10.1007/s00204-018-2296-7',
'article-title': 'Evaluation of FSH, LH, testosterone levels and semen parameters in male '
'boron workers under extreme exposure conditions',
'volume': '92',
'author': 'Duydu',
'year': '2018',
'journal-title': 'Arch Toxicol'},
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'key': '2024102103415428900_ref20',
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'first-page': '3138',
'DOI': '10.1007/s12011-021-02946-1',
'article-title': 'Evaluation of serum trace element levels and biochemical parameters of '
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'volume': '1-9',
'author': 'Kocak, OF',
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'year': '2020',
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