Is Hydroxychloroquine a Possible Post-Exposure Prophylaxis Drug to Limit the Transmission to Health Care Workers Exposed to COVID19?
et al., Clin. Infect. Dis., 2020 Mar 24, doi:10.1093/cid/ciaa320, Mar 2020
HCQ for COVID-19
1st treatment shown to reduce risk in
March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
CQ and HCQ inhibit replication at early stages of infection, no similar effect reported for other drugs which are only able to interfere after cell infection. Large volume of existing data on safety. (8/23: we corrected the classification of this study)
Pagliano et al., 24 Mar 2020, peer-reviewed, 5 authors.
2019 Novel Coronavirus Is Undergoing Active Recombination
Clinical Infectious Diseases, doi:10.1093/cid/ciaa219
www. maths.otago.ac.nz/~dbryant/software/phimanual. pdf 9. Jiang X, Robertson DL. nCoV's relationship to bat coronaviruses and recombination signals (no snakes)-no evidence the 2019-nCoV lineage is recombinant. 2020.
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Yao, Ye, Zhang, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Yao, Ye, Zhang, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin Infect Dis
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