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Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients

Morán Blanco et al., Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.101989
Apr 2021  
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10th treatment shown to reduce risk in December 2020, now with p = 0.00006 from 15 studies.
Lower risk for mortality, recovery, and cases.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective 84 elderly nursing home residents in Spain showing no mortality, hospitalization, or ICU admission with early treatment with antihistamines alone or in combination with azithromycin.
Study covers PPIs and antihistamine H1RAs.
Morán Blanco et al., 30 Apr 2021, retrospective, Spain, peer-reviewed, mean age 85.0, 6 authors, study period March 2020 - April 2020. Contact: kvillar@jccm.es.
This PaperH1RAsAll
Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients
Juan Ignacio Morán Blanco, Judith A Alvarenga Bonilla, Sakae Homma, Kazuo Suzuki, Philip Fremont-Smith, Karina Villar Gómez De Las Heras
Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.101989
Background: Between March and April 2020, 84 elderly patients with suspected COVID-19 living in two nursing homes of Yepes, Toledo (Spain) were treated early with antihistamines (dexchlorpheniramine, cetirizine or loratadine), adding azithromycin in the 25 symptomatic cases. The outcomes are retrospectively reported. The primary endpoint is the fatality rate of COVID-19. The secondary endpoints are the hospital and ICU admission rates. Endpoints were compared with the official Spanish rates for the elderly. The mean age of our population was 85 and 48% were over 80 years old. No hospital admissions, deaths, nor adverse drug effects were reported in our patient population. By the end of June, 100% of the residents had positive serology for COVID-19. Although clinical trials are needed to determine the efficacy of both drugs in the treatment of COVID-19, this analysis suggests that primary care diagnosis and treatment with antihistamines, plus azithromycin in selected cases, may treat COVID-19 and prevent progression to severe disease in elderly patients.
Declaration of competing interest The authors declare no conflict of interest. Abbreviations Authors' contributions JIMB devised the clinical guidance. JIMB and JAB carried out patients' diagnosis, prescription of treatments and the follow-up until their full recovery. JAB performed data extraction from the medical records. KVGH wrote the first draft, made the data analysis and graphs, reviewed the bibliography and wrote the argument. SH, KS, JAB and PFS reviewed and refined the final document. PFS was supported under Air Force Contract No. FA8702-15-D-0001. Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. Air Force. All authors reviewed and approved this manuscript.
References
Ambrosch, Borgmann, Rihoux, König, Effect of the H1 receptor antagonist cetirizine on the stimulated expression of adhesion molecules and the activation of NFκB in human endothelial cells, Int. Arch. Allergy Immunol, doi:10.1159/000053758
Arnold, Rihoux, König, Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549), Clin. Exp. Allergy, doi:10.1046/j.1365-2222.1999.00630.x
Aydin, Aydin, Could Antihistamines Help in the Treatment and Spread of COVID-19 Via Re-Modulating Cytokines and by Reducing Sneezing, Acta Scientific Nutritional Health
Beigelman, Does azithromycin modify viral load during severe RSV bronchiolitis?, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2015.06.011
Cataldi, Maurer, Taglialatela, Church, Cardiac safety of secondgeneration H1-antihistamines when updosed in chronic spontaneous urticaria, Clin. Exp. Allergy, doi:10.1111/cea.13500
Chang, A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand, Allergy Eur. J. Allergy Clin. Immunol, doi:10.1111/all.14186
Chen, Charles, Repurposing an old drug: a low-cost Allergy medication provides new Hope for hepatitis C patients, Hepatology, doi:10.1002/hep.28028
Cheng, Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor, Antivir. Res, doi:10.1016/j.antiviral.2017.06.015
Damle, Vourvahis, Wang, Leaney, Corrigan, Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID-19, Clin. Pharmacol. Ther, doi:10.1002/cpt.1857
Freedberg, Famotidine use is Associated with improved clinical outcomes in hospitalized COVID-19 patients: a propensity score matched retrospective cohort study, Gastroenterology, doi:10.1053/j.gastro.2020.05.053
Gautret, Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int. J. Antimicrob. Agents, doi:10.1016/j.ijantimicag.2020.105949
He, Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection, Sci. Transl. Med, doi:10.1126/scitranslmed.3010286
Hogan, Dual-histamine receptor blockade with cetirizine -famotidine reduces pulmonary symptoms in COVID-19 patients, Pulm. Pharmacol. Therapeut, doi:10.1016/j.pupt.2020.101942
Homolak, Kodvanj, Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, Int. J. Antimicrob. Agents, doi:10.1016/j.ijantimicag.2020.106044
Igualdad, Ficha Técnica de Zitromax
Janowitz, Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series, Gut, doi:10.1136/gutjnl-2020-321852
Machiels, Reply to Gautret et al: hydroxychloroquine sulfate and azithromycin for COVID-19 : what is the evidence and what are the risks ?, Int. J. Antimicrob. Agents, doi:10.1016/j.ijantimicag.2020.106056
Maciá-Martínez, Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP): a data resource for pharmacoepidemiology in Spain, Pharmacoepidemiol. Drug Saf, doi:10.1002/pds.5006
Mather, Seip, Mckay, Impact of famotidine use on clinical outcomes of hospitalized patients with COVID-19, Am. J. Gastroenterol, doi:10.14309/ajg.0000000000000832
Menzel, Akbarshahi, Bjermer, Uller, Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients, Sci. Rep, doi:10.1038/srep28698
Min, Jang, Macrolide therapy in respiratory viral infections, Mediat. Inflamm, doi:10.1155/2012/649570
Mingorance, Selective inhibition of hepatitis c virus infection by hydroxyzine and benztropine, Antimicrob. Agents Chemother, doi:10.1128/AAC.02619-14
Mondejar-Lopez, Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: incidence and results of the national CF-COVID19-Spain survey, Respir. Med, doi:10.1016/j.rmed.2020.106062
Mosquera, Role of prophylactic azithromycin to reduce airway inflammation and mortality in a RSV mouse infection model, Pediatr. Pulmonol, doi:10.1002/ppul.23956
Murphy, Azithromycin alters macrophage phenotype, J. Antimicrob. Chemother, doi:10.1093/jac/dkn007
Médicos Sin, Msf, Little, TOO LATE : the unacceptable neglect of the elderly in care
Mégarbane, Scherrmann, Hydroxychloroquine and azithromycin to treat patients with COVID-19: both friends and foes?, J. Clin. Pharmacol, doi:10.1002/jcph.1646
Observass, Situación COVID-19 en Centros residenciales para personas mayores
Ohe, Macrolide treatment for COVID-19: will this be the way forward?, Biosci, Trends, doi:10.5582/bst.2020.03058
Papi, Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells, J. Allergy Clin. Immunol, doi:10.1067/mai.2001.116861
Romero, COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn, PloS One, doi:10.1371/journal.pone.0241030
Samimagham, The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: a structured summary of a study protocol for a randomised controlled trial, Trials, doi:10.1186/s13063-020-04773-6
Scherrmann, Intracellular ABCB1 as a possible mechanism to explain the synergistic effect of hydroxychloroquine-azithromycin combination in COVID-19 therapy, AAPS J, doi:10.1208/s12248-020-00465-w
Schwartz, Suskind, Azithromycin and COVID-19: prompt early use at first signs of this infection in adults and children, an approach worthy of consideration, Dermatol. Ther, doi:10.1111/dth.13785
Shereen, Khan, Kazmi, Bashir, Siddique, COVID-19 infection: origin, transmission, and characteristics of human coronaviruses, J. Adv. Res, doi:10.1016/j.jare.2020.03.005
Touret, In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication, Sci. Rep, doi:10.1038/s41598-020-70143-6
Tran, Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process, J. Antibiot. (Tokyo), doi:10.1038/s41429-019-0204-x
Wang, Xia, Zou, Lu, Erythromycin estolate inhibits zika virus infection by blocking viral entry as a viral inactivator, Viruses, doi:10.3390/v11111064
Yamaya, Clarithromycin inhibits type A seasonal influenza virus infection in human airway epithelial cells, J. Pharmacol. Exp. Therapeut, doi:10.1124/jpet.109.162149
Zhou, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, doi:10.1016/S0140-6736(20)30566-3
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Immunol.'}, { 'key': '10.1016/j.pupt.2021.101989_bib22', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/s41598-020-70143-6', 'article-title': 'In vitro screening of a FDA approved chemical library reveals potential ' 'inhibitors of SARS-CoV-2 replication', 'volume': '10', 'author': 'Touret', 'year': '2020', 'journal-title': 'Sci. Rep.'}, { 'key': '10.1016/j.pupt.2021.101989_bib23', 'doi-asserted-by': 'crossref', 'first-page': '81', 'DOI': '10.1124/jpet.109.162149', 'article-title': 'Clarithromycin inhibits type A seasonal influenza virus infection in ' 'human airway epithelial cells', 'volume': '333', 'author': 'Yamaya', 'year': '2010', 'journal-title': 'J. Pharmacol. Exp. Therapeut.'}, { 'key': '10.1016/j.pupt.2021.101989_bib24', 'doi-asserted-by': 'crossref', 'article-title': 'Macrolide therapy in respiratory viral infections', 'author': 'Min', 'year': '2012', 'journal-title': 'Mediat. Inflamm.', 'DOI': '10.1155/2012/649570'}, { 'key': '10.1016/j.pupt.2021.101989_bib25', 'first-page': '159', 'article-title': 'Macrolide treatment for COVID-19: will this be the way forward? Biosci', 'volume': '14', 'author': 'Ohe', 'year': '2020', 'journal-title': 'Trends'}, { 'key': '10.1016/j.pupt.2021.101989_bib26', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.rmed.2020.106062', 'article-title': 'Impact of SARS-CoV-2 infection in patients with cystic fibrosis in ' 'Spain: incidence and results of the national CF-COVID19-Spain survey', 'volume': '170', 'author': 'Mondejar-Lopez', 'year': '2020', 'journal-title': 'Respir. Med.'}, {'key': '10.1016/j.pupt.2021.101989_bib27', 'author': 'European Cystic Fibrosis Society'}, { 'key': '10.1016/j.pupt.2021.101989_bib28', 'doi-asserted-by': 'crossref', 'first-page': '24', 'DOI': '10.1016/j.antiviral.2017.06.015', 'article-title': 'Identification of a coumarin-based antihistamine-like small molecule as ' 'an anti-filoviral entry inhibitor', 'volume': '145', 'author': 'Cheng', 'year': '2017', 'journal-title': 'Antivir. Res.'}, { 'key': '10.1016/j.pupt.2021.101989_bib29', 'doi-asserted-by': 'crossref', 'first-page': '1911', 'DOI': '10.1002/hep.28028', 'article-title': 'Repurposing an old drug: a low-cost Allergy medication provides new ' 'Hope for hepatitis C patients', 'volume': '62', 'author': 'Chen', 'year': '2015', 'journal-title': 'Hepatology'}, { 'key': '10.1016/j.pupt.2021.101989_bib30', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1126/scitranslmed.3010286', 'article-title': 'Repurposing of the antihistamine chlorcyclizine and related compounds ' 'for treatment of hepatitis C virus infection', 'volume': '7', 'author': 'He', 'year': '2015', 'journal-title': 'Sci. Transl. Med.'}, { 'key': '10.1016/j.pupt.2021.101989_bib31', 'doi-asserted-by': 'crossref', 'first-page': '3451', 'DOI': '10.1128/AAC.02619-14', 'article-title': 'Selective inhibition of hepatitis c virus infection by hydroxyzine and ' 'benztropine', 'volume': '58', 'author': 'Mingorance', 'year': '2014', 'journal-title': 'Antimicrob. Agents Chemother.'}, { 'key': '10.1016/j.pupt.2021.101989_bib32', 'doi-asserted-by': 'crossref', 'first-page': '221', 'DOI': '10.1067/mai.2001.116861', 'article-title': 'Effect of desloratadine and loratadine on rhinovirus-induced ' 'intercellular adhesion molecule 1 upregulation and promoter activation ' 'in respiratory epithelial cells', 'volume': '108', 'author': 'Papi', 'year': '2001', 'journal-title': 'J. Allergy Clin. Immunol.'}, { 'key': '10.1016/j.pupt.2021.101989_bib33', 'first-page': '172', 'article-title': 'Could Antihistamines Help in the Treatment and Spread of COVID-19 Via ' 'Re-Modulating Cytokines and by Reducing Sneezing?', 'volume': '4.4', 'author': 'Aydin', 'year': '2020', 'journal-title': 'Acta Scientific Nutritional Health'}, { 'key': '10.1016/j.pupt.2021.101989_bib34', 'doi-asserted-by': 'crossref', 'first-page': '362', 'DOI': '10.1159/000053758', 'article-title': 'Effect of the H1 receptor antagonist cetirizine on the stimulated ' 'expression of adhesion molecules and the activation of NFκB in human ' 'endothelial cells', 'volume': '124', 'author': 'Ambrosch', 'year': '2001', 'journal-title': 'Int. Arch. Allergy Immunol.'}, { 'key': '10.1016/j.pupt.2021.101989_bib35', 'doi-asserted-by': 'crossref', 'first-page': '1681', 'DOI': '10.1046/j.1365-2222.1999.00630.x', 'article-title': 'Cetirizine counter-regulates interleukin-8 release from human ' 'epithelial cells (A549)', 'volume': '29', 'author': 'Arnold', 'year': '1999', 'journal-title': 'Clin. Exp. Allergy'}, { 'key': '10.1016/j.pupt.2021.101989_bib36', 'doi-asserted-by': 'crossref', 'first-page': '1059', 'DOI': '10.1016/j.ijantimicag.2020.105949', 'article-title': 'Hydroxychloroquine and azithromycin as a treatment of COVID-19: results ' 'of an open-label non-randomized clinical trial', 'volume': '56', 'author': 'Gautret', 'year': '2020', 'journal-title': 'Int. J. Antimicrob. 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