Pharmacological Immunomodulation via Collagen–Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19 Through Similar Mechanisms of Action Involving the JAK/STAT Signalling Pathway: A Pilot Study

Mendieta-Zerón et al., Advances in Respiratory Medicine, doi:10.3390/arm93040024, Jul 2025

https://c19early.org/mendietazeron.html

Prospective single-centre open-label pilot study of 36 hospitalised adults with severe COVID-19 showing that adding collagen-polyvinylpyrrolidone or pirfenidone to standard dexamethasone + enoxaparin care shortened mean hospital stay and reduced ICU admission, however there was no significant difference in mortality.

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Mendieta-Zerón et al., 18 Jul 2025, peer-reviewed, 15 authors.

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Pharmacological Immunomodulation via Collagen-Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19 Through Similar Mechanisms of Action Involving the JAK/STAT Signalling Pathway: A Pilot Study

H ; Cruz-Arenas, E ; Díaz-Meza, S ; Cabrera-Wrooman, A ; Mandujano-Tinoco, E A ; Salgado, R M ; Tovar, Hugo Mendieta-Zerón, Esteban Cruz-Arenas, Salvador Díaz-Meza, Alejandro Cabrera-Wrooman, Edna Ayerim Mandujano-Tinoco, Rosa M Salgado, Hugo Tovar, Daniel Muñiz-García, Laura Julieta Orozco-Castañeda, Sonia Hernández-Enríquez, Miriam Deyanira Rodríguez-Piña, Ana Sarahí Mulia-Soto, José Meneses-Calderón, Paul Mondragón-Terán, Edgar Krötzsch

doi:10.3390/arm93040024

What are the main findings? • Collagen-polyvinylpyrrolidone and pirfenidone have been shown to be therapeutically useful in patients with severe COVID-19. • Collagen-polyvinylpyrrolidone or pirfenidone could control the inflammation associated with COVID-19, perhaps by regulating the JAK/STAT pathway. What is the implication of the main findings? • Collagen-polyvinylpyrrolidone and pirfenidone can be considered as adjuvant therapies for the treatment of infectious diseases involving exacerbated inflammation.

Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflicts of interest. Abbreviations The following abbreviations are used in this manuscript:

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