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All Studies   Meta Analysis    Recent:   

Insights from nanomedicine into chloroquine efficacy against COVID-19

Hu et al., Nature Nanotechnology, 15, 247–249, 2020, doi:10.1038/s41565-020-0674-9
Mar 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 418 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
5,000+ studies for 104 treatments. c19hcq.org
CQ is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.
Hu et al., 23 Mar 2020, peer-reviewed, 3 authors.
This PaperHCQAll
Insights from nanomedicine into chloroquine efficacy against COVID-19 Chloroquine -an approved malaria drug -is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.
Competing interests The authors declare no competing interests.
References
Dowall, None, J. Gen. Virol
Gao, Tian, Yang, None, X. Biosci. Trends, doi:10.5582/bst.2020.01047
Gentile, None, Future Oncol
Haladyj, Sikora, Felis-Giemza, Olesinska, None, M. Reumatologia
Hempelmann, None, E. Parasitol. Res
Inoue, None, J. Virol
Keyaerts, None, Antimicrob. Agents Chemother
Li, None, Nature
Liu, None, Cell Discov
Madrid, None, PLoS One
Miller, None, Dev. Cell
Pelt, None, Pharmacol. Ther
Roques, None, Viruses
Savarino, Boelaert, Cassone, Majori, Cauda, None, Lancet Infect. Dis
Vincent, None, Virol. J
Wang, None, Cell Res
Wang, None, Cell Res
Wolfram, Ferrari, None, Nano Today
Wolfram, None, Sci Rep
Wrapp, None, Science
Wu, Li, Peng, Li, Proc. Natl Acad. Sci
Yao, None, Clin. Infect. Dis, doi:10.1093/cid/ciaa237
Zhu, None, N. Engl. J. Med
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