Satisfaction with Government Recommended Pre-Procedural Mouth Rinses in the Mitigation of Covid-19 in Hong Kong SAR: A Triple Blind Randomized Controlled Clinical Trial

Huang et al., Journal of Dentistry, doi:10.1016/j.jdent.2024.105082, May 2024

Chlorhexidine for COVID-19

53rd treatment shown to reduce risk in November 2023, now with p < 0.0000000001 from 5 studies.
Lower risk for progression, cases, and viral clearance.

No treatment is 100% effective.
Protocols combine treatments.

RCT 228 dental patients showing high satisfaction and acceptability of three pre-procedural mouthrinses (povidone-iodine, hydrogen peroxide, and chlorhexidine digluconate) recommended by the Hong Kong government for mitigating COVID-19 transmission. There was no significant difference in satisfaction and acceptability rates.
Study covers povidone-iodine, hydrogen peroxide, and chlorhexidine.
Huang et al., 16 May 2024, Double Blind Randomized Controlled Trial, China, peer-reviewed, 7 authors.
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"article-title": "Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review", "author": "Solderer", "doi-asserted-by": "crossref", "first-page": "21", "journal-title": "Clinical Oral Investigations", "key": "10.1016/j.jdent.2024.105082_bib0002", "volume": "23", "year": "2019" }, { "DOI": "10.3390/curroncol30010074", "article-title": "Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials", "author": "Colella", "doi-asserted-by": "crossref", "first-page": "967", "journal-title": "Current Oncolology", "key": "10.1016/j.jdent.2024.105082_bib0003", "volume": "30", "year": "2023" }, { "DOI": "10.1016/j.identj.2023.08.009", "article-title": "Antimicrobial Mouthwashes: An Overview of Mechanisms-What Do We Still Need to Know?", "author": "Brookes", "doi-asserted-by": "crossref", "first-page": "S64", "journal-title": "International Dental Journal", "key": "10.1016/j.jdent.2024.105082_bib0004", "volume": "73", "year": "2023" }, { "DOI": "10.17219/dmp/134290", "article-title": "Evaluation of the effects of different mouthrinses on dental remineralization", "author": "Basak", "doi-asserted-by": "crossref", "first-page": "219", "issue": "2", "journal-title": "Dent Med Probl", "key": "10.1016/j.jdent.2024.105082_bib0005", "volume": "60", "year": "2023" }, { "DOI": "10.1034/j.1600-0501.2002.130102.x", "article-title": "The effects of an immediately pre-surgical chlorhexidine oral rinse on the bacterial contaminants of bone debris collected during dental implant surgery", "author": "Young", "doi-asserted-by": "crossref", "first-page": "20", "journal-title": "Clinical Oral Implants Research", "key": "10.1016/j.jdent.2024.105082_bib0006", "volume": "13", "year": "2002" }, { "article-title": "Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19infection to improve patient outcomes and to protect healthcare workers treating them", "author": "Burton", "issue": "9", "journal-title": "Cochrane Database Systematic Reviews", "key": "10.1016/j.jdent.2024.105082_bib0007", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.jobcr.2022.05.010", "article-title": "Top 50 covid and oral health articles: A 2021 altmetric analysis", "author": "Grillo", "doi-asserted-by": "crossref", "first-page": "458", "issue": "4", "journal-title": "Journal of Oral Biology and Craniofacial Research", "key": "10.1016/j.jdent.2024.105082_bib0008", "volume": "12", "year": "2022" }, { "DOI": "10.1016/j.mehy.2020.110436", "article-title": "Can preprocedural mouthrinses reduce SARS-CoV-2 load in dental aerosols?", "author": "Reis", "doi-asserted-by": "crossref", "journal-title": "Medical Hypotheses", "key": "10.1016/j.jdent.2024.105082_bib0009", "volume": "146", "year": "2021" }, { "DOI": "10.1099/jgv.0.001578", "article-title": "Effective in vitro inactivation of SARS-CoV-2 by commercially available 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"10.1016/j.identj.2021.04.002", "article-title": "CoDER Working Group. A Review of Aerosol Generation Mitigation in International Dental Guidance", "author": "Robertson", "doi-asserted-by": "crossref", "first-page": "203", "issue": "2", "journal-title": "International Dental Journal", "key": "10.1016/j.jdent.2024.105082_bib0013", "volume": "72", "year": "2022" }, { "key": "10.1016/j.jdent.2024.105082_bib0014", "unstructured": "HKSAR, D.o.H.Update on COVID-19. 2020 [cited 2023 15 July]; Available from: https://www.chp.gov.hk/files/pdf/letters_to_dentists_20200610.pdf." }, { "DOI": "10.1016/j.cmi.2019.04.012", "article-title": "Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study", "author": "To", "doi-asserted-by": "crossref", "first-page": "1539", "issue": "12", "journal-title": "Clinical Microbiology and Infection", "key": "10.1016/j.jdent.2024.105082_bib0015", "volume": "25", "year": "2019" }, { "DOI": "10.1016/j.puhe.2021.02.001", "article-title": "Mitigation 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"DOI": "10.1186/s12903-017-0400-7", "article-title": "Comparing the effect of 0.06% -, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial", "author": "Haydari", "doi-asserted-by": "crossref", "first-page": "118", "issue": "1", "journal-title": "BMC Oral Health", "key": "10.1016/j.jdent.2024.105082_bib0019", "volume": "17", "year": "2017" }, { "DOI": "10.4103/jisp.jisp_414_18", "article-title": "Hydrogen peroxide masks the bitterness of chlorhexidine mouthwash without affecting its antibacterial activity", "author": "Mathurasai", "doi-asserted-by": "crossref", "first-page": "119", "issue": "2", "journal-title": "Journal of Indian Society of Periodontology", "key": "10.1016/j.jdent.2024.105082_bib0020", "volume": "23", "year": "2019" }, { "DOI": "10.1136/bmj.321.7259.504", "article-title": "Statistics notes: blinding in clinical trials and other studies", "author": "Day", "doi-asserted-by": "crossref", "first-page": "504", "issue": "7259", "journal-title": "British Medical Journal", "key": "10.1016/j.jdent.2024.105082_bib0021", "volume": "321", "year": "2000" }, { "DOI": "10.1136/bmj.a1035", "article-title": "Critically appraising qualitative research", "author": "Kuper", "doi-asserted-by": "crossref", "first-page": "a1035", "journal-title": "British Medical Journal", "key": "10.1016/j.jdent.2024.105082_bib0022", "volume": "337", "year": "2008" }, { "DOI": "10.1136/bmj.b3425", "article-title": "Critical reflections on the rise of qualitative research", "author": "Pope", "doi-asserted-by": "crossref", "first-page": "b3425", "journal-title": "British Medical Journal", "key": "10.1016/j.jdent.2024.105082_bib0023", "volume": "339", "year": "2009" }, { "DOI": "10.1136/bmj.39602.690162.47", "article-title": "Grounded theory, mixed methods, and action research", "author": "Lingard", "doi-asserted-by": "crossref", "first-page": "a567", "journal-title": "British Medical Journal", "key": "10.1016/j.jdent.2024.105082_bib0024", "volume": "337", "year": "2008" }, { "DOI": "10.1136/bmj.o2503", "article-title": "We need both quantitative and qualitative data to prove the value of health visiting", "author": "Clery", "doi-asserted-by": "crossref", "first-page": "o2503", "journal-title": "British Medical Journal", "key": "10.1016/j.jdent.2024.105082_bib0025", "volume": "379", "year": "2022" }, { "article-title": "How Does Cost-Effectiveness Analysis Inform Health Care Decisions?", "author": "Kim", "first-page": "E639", "issue": "8", "journal-title": "Journal of Ethics American Medical Association", "key": "10.1016/j.jdent.2024.105082_bib0026", "volume": "23", "year": "2021" } ], "reference-count": 26, "references-count": 26, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0300571224002513" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Satisfaction 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