Supplementary Data — Dornase alfa for COVID-19: real-time meta-analysis of 3 studies

@CovidAnalysis, October 2026, Version 2V2 (V1 2025)

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c19early.org

October 2026

Dornase alfa COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Files (RCT)−9%1.09 · 0.61–1.92death39 (n)88 (n)I-SPY COVID Files (RCT)−32%1.32 · 0.84–2.08no recov.39 (n)88 (n)I-SPY COVID Porter (RCT)−130%2.30 · 0.10–52.10death1/300/9COVASE Porter (RCT)53%0.47 · 0.06–3.86death30 (n)69 (n)COVASE Porter (RCT)10%0.90 · 0.11–7.63no disch.3/301/9COVASE Åkesson (SB RCT)−11%1.11 · 0.30–4.12death4/364/40 Åkesson (SB RCT)−2%1.02 · 0.62–1.69no recov.36 (n)40 (n)

00.511.52+

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← Dornase alfa
reduces riskDornase alfa
increases risk →

Fig. S1. All outcomes.