Lipid metabolism, viral infection, and antiviral immunity: a new host-pathogen interface

DOI record: { "DOI": "10.3389/fcimb.2026.1765502", "ISSN": [ "2235-2988" ], "URL": "http://dx.doi.org/10.3389/fcimb.2026.1765502", "abstract": "<jats:p>Viral infections pose significant challenges to global health. Lipid metabolism plays a crucial role in various biological processes, including cell membrane structure, signaling, and energy homeostasis. Recent studies have highlighted the intricate relationship between lipid metabolism and viral infections, revealing how viruses exploit host lipid pathways to facilitate their replication and assembly. This review aims to elucidate the mechanisms by which viruses manipulate lipid metabolism and the subsequent impact on antiviral immunity. We systematically analyze the biological basis of lipid synthesis and degradation, emphasizing the role of lipids in immune cell function and the regulation of antiviral responses. Furthermore, we explore how altered lipid metabolism can influence immune responses in disease states, providing insights into the differential utilization of lipid pathways by various viruses. This review highlights suggest potential therapeutic strategies, including the development of antiviral drugs targeting lipid metabolism, modulation of lipid pathways to enhance immune responses, and combination therapies that integrate lipid metabolism modulation with conventional antiviral treatments. Future research directions are proposed, focusing on the interaction between lipid metabolism and emerging viral strains, the application of metabolomics in viral infection studies. This comprehensive review underscores the significance of lipid metabolism as a novel host-pathogen interface, paving the way for innovative therapeutic approaches in combating viral infections.</jats:p>", "alternative-id": [ "10.3389/fcimb.2026.1765502" ], "article-number": "1765502", "author": [ { "affiliation": [ { "name": "Department of Pharmacy, Yiyang Medical College", "place": [ "Yiyang, China" ] } ], "family": "Yang", "given": "Li Jun", "sequence": "first" }, { "affiliation": [ { "name": "Department of Pharmacy, Yiyang Medical College", "place": [ "Yiyang, China" ] } ], "family": "Tang", "given": "Min", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Gastroenterology, Yiyang Central Hospital", "place": [ "Yiyang, China" ] } ], "family": "Yang", "given": "Le", "sequence": "additional" } ], "container-title": "Frontiers in Cellular and Infection Microbiology", "container-title-short": "Front. Cell. Infect. Microbiol.", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2026, 3, 5 ] ], "date-time": "2026-03-05T06:58:13Z", "timestamp": 1772693893000 }, "deposited": { "date-parts": [ [ 2026, 3, 5 ] ], "date-time": "2026-03-05T06:58:15Z", "timestamp": 1772693895000 }, "indexed": { "date-parts": [ [ 2026, 3, 5 ] ], "date-time": "2026-03-05T07:57:05Z", "timestamp": 1772697425708, "version": "3.50.1" }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2026, 3, 5 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2026, 3, 5 ] ], "date-time": "2026-03-05T00:00:00Z", "timestamp": 1772668800000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fcimb.2026.1765502/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2026, 3, 5 ] ] }, "published-online": { "date-parts": [ [ 2026, 3, 5 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.1007/s00216-023-04825-1", "article-title": "Characterization of the cellular lipid composition during SARS-CoV-2 infection", "author": "Abdel-Megied", "doi-asserted-by": "publisher", "first-page": "5269", "journal-title": "Anal. Bioanal Chem.", "key": "B1", "volume": "415", "year": "2023" }, { "DOI": "10.3390/ijms21103544", "article-title": "The role of lipid metabolism in COVID-19 virus infection and as a drug target", "author": "Abu-Farha", "doi-asserted-by": "publisher", "journal-title": "Int. J. Mol. Sci.", "key": "B2", "volume": "21", "year": "2020" }, { "DOI": "10.1016/j.obmed.2020.100283", "article-title": "Association of high level gene expression of ACE2 in adipose tissue with mortality of COVID-19 infection in obese patients", "author": "Al-Benna", "doi-asserted-by": "publisher", "journal-title": "Obes. Med.", "key": "B3", "volume": "19", "year": "2020" }, { "DOI": "10.1128/spectrum.03893-22", "article-title": "ISG15 is a novel regulator of lipid metabolism during vaccinia virus infection", "author": "Albert", "doi-asserted-by": "publisher", "first-page": "e0389322", "journal-title": "Microbiol. Spectr.", "key": "B4", "volume": "10", "year": "2022" }, { "DOI": "10.3390/ijms242115693", "article-title": "Review of eukaryote cellular membrane lipid composition, with special attention to the fatty acids", "author": "Ali", "doi-asserted-by": "publisher", "journal-title": "Int. J. Mol. Sci.", "key": "B5", "volume": "24", "year": "2023" }, { "DOI": "10.1002/rmv.2214", "article-title": "Lipid-based therapies against SARS-CoV-2 infection", "author": "Alketbi", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Rev. Med. Virol.", "key": "B6", "volume": "31", "year": "2021" }, { "DOI": "10.1073/pnas.97.7.3254", "article-title": "Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast", "author": "Bagnat", "doi-asserted-by": "publisher", "first-page": "3254", "journal-title": "Proc. Natl. Acad. Sci. U S A.", "key": "B7", "volume": "97", "year": "2000" }, { "DOI": "10.3390/ijms22115676", "article-title": "Ceramide and related molecules in viral infections", "author": "Beckmann", "doi-asserted-by": "publisher", "journal-title": "Int. J. Mol. Sci.", "key": "B8", "volume": "22", "year": "2021" }, { "DOI": "10.1038/s41598-022-14050-y", "article-title": "Small-molecule metabolome identifies potential therapeutic targets against COVID-19", "author": "Bennet", "doi-asserted-by": "publisher", "first-page": "10029", "journal-title": "Sci. Rep.", "key": "B9", "volume": "12", "year": "2022" }, { "DOI": "10.1002/rmv.588", "article-title": "Role of multivesicular bodies and their components in the egress of enveloped RNA viruses", "author": "Calistri", "doi-asserted-by": "publisher", "first-page": "31", "journal-title": "Rev. Med. Virol.", "key": "B10", "volume": "19", "year": "2009" }, { "DOI": "10.1016/j.diabet.2020.10.001", "article-title": "et al; Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study", "author": "Cariou", "doi-asserted-by": "publisher", "first-page": "101202", "journal-title": "Diabetes Metab.", "key": "B11", "volume": "47", "year": "2021" }, { "DOI": "10.1007/978-3-031-65187-8_15", "article-title": "Virus-receptor interactions and receptor-mediated virus entry into host cells", "author": "Casasnovas", "doi-asserted-by": "publisher", "first-page": "533", "journal-title": "Subcell Biochem.", "key": "B12", "volume": "105", "year": "2024" }, { "DOI": "10.1101/cshperspect.a040576", "article-title": "Lipid metabolism", "author": "Chandel", "doi-asserted-by": "publisher", "journal-title": "Cold Spring Harb. Perspect. Biol.", "key": "B13", "volume": "13", "year": "2021" }, { "DOI": "10.1016/j.micpath.2023.106002", "article-title": "Comprehensive analysis of lipid metabolism in influenza virus infection", "author": "Chen", "doi-asserted-by": "publisher", "journal-title": "Microb. Pathog.", "key": "B14", "volume": "175", "year": "2023" }, { "DOI": "10.3389/fmicb.2024.1532678", "article-title": "ASFV infection induces lipid metabolic disturbances and promotes viral replication", "author": "Chu", "doi-asserted-by": "publisher", "journal-title": "Front. Microbiol.", "key": "B15", "volume": "15", "year": "2024" }, { "DOI": "10.1186/s12964-019-0452-1", "article-title": "Roles of phosphatidylserine exposed on the viral envelope and cell membrane in HIV-1 replication", "author": "Chua", "doi-asserted-by": "publisher", "first-page": "132", "journal-title": "Cell Commun. Signal.", "key": "B16", "volume": "17", "year": "2019" }, { "DOI": "10.23812/20-2EDIT", "article-title": "Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19", "author": "Conti", "doi-asserted-by": "publisher", "first-page": "1629", "journal-title": "J. Biol. Regul. Homeost Agents.", "key": "B17", "volume": "34", "year": "2020" }, { "DOI": "10.1016/j.celrep.2024.114288", "article-title": "G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds", "author": "Cooper", "doi-asserted-by": "publisher", "journal-title": "Cell Rep.", "key": "B18", "volume": "43", "year": "2024" }, { "DOI": "10.21769/BioProtoc.4742", "article-title": "Mass spectrometry-based lipidomics, lipid bioenergetics, and web tool for lipid profiling and quantification in human cells", "author": "Cui", "doi-asserted-by": "publisher", "first-page": "e4742", "journal-title": "Bio Protoc.", "key": "B19", "volume": "13", "year": "2023" }, { "DOI": "10.1007/s00232-020-00135-0", "article-title": "Various facets of pathogenic lipids in infectious diseases: exploring virulent lipid-host interactome and their druggability", "author": "Dadhich", "doi-asserted-by": "publisher", "first-page": "399", "journal-title": "J. Membr Biol.", "key": "B20", "volume": "253", "year": "2020" }, { "DOI": "10.1016/j.antiviral.2024.105942", "article-title": "Virus infection and sphingolipid metabolism", "author": "Dai", "doi-asserted-by": "publisher", "journal-title": "Antiviral Res.", "key": "B21", "volume": "228", "year": "2024" }, { "DOI": "10.3389/fimmu.2022.791267", "article-title": "Coronavirus infection and cholesterol metabolism", "author": "Dai", "doi-asserted-by": "publisher", "journal-title": "Front. Immunol.", "key": "B22", "volume": "13", "year": "2022" }, { "DOI": "10.1371/journal.ppat.1009127", "article-title": "Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators", "author": "Dias", "doi-asserted-by": "publisher", "first-page": "e1009127", "journal-title": "PloS Pathog.", "key": "B23", "volume": "16", "year": "2020" }, { "DOI": "10.3390/nu13072421", "article-title": "Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: an update for 2021", "author": "Djuricic", "doi-asserted-by": "publisher", "journal-title": "Nutrients.", "key": "B24", "volume": "13", "year": "2021" }, { "DOI": "10.1002/cm.21067", "article-title": "Phosphoinositides and cytokinesis: the “PIP” of the iceberg", "author": "Echard", "doi-asserted-by": "publisher", "first-page": "893", "journal-title": "Cytoskeleton (Hoboken).", "key": "B25", "volume": "69", "year": "2012" }, { "DOI": "10.1096/fj.201900428RR", "article-title": "Atorvastatin restricts the ability of influenza virus to generate lipid droplets and severely suppresses the replication of the virus", "author": "Episcopio", "doi-asserted-by": "publisher", "first-page": "9516", "journal-title": "FASEB J.", "key": "B26", "volume": "33", "year": "2019" }, { "DOI": "10.1515/hsz-2017-0146", "article-title": "Immune-regulation and -functions of eicosanoid lipid mediators", "author": "Esser-von Bieren", "doi-asserted-by": "publisher", "first-page": "1177", "journal-title": "Biol. Chem.", "key": "B27", "volume": "398", "year": "2017" }, { "DOI": "10.1038/s41598-022-21177-5", "article-title": "Remnant cholesterol levels are associated with severity and death in COVID-19 patients", "author": "Fabre", "doi-asserted-by": "publisher", "first-page": "17584", "journal-title": "Sci. Rep.", "key": "B28", "volume": "12", "year": "2022" }, { "DOI": "10.1080/1040841X.2023.2224424", "article-title": "Interplay between lipid metabolism, lipid droplets and RNA virus replication", "author": "Farías", "doi-asserted-by": "publisher", "first-page": "515", "journal-title": "Crit. Rev. Microbiol.", "key": "B29", "volume": "50", "year": "2024" }, { "DOI": "10.1016/j.molmed.2014.11.003", "article-title": "Hepatitis C virus and lipid droplets: finding a niche", "author": "Filipe", "doi-asserted-by": "publisher", "first-page": "34", "journal-title": "Trends Mol. Med.", "key": "B30", "volume": "21", "year": "2015" }, { "DOI": "10.3390/metabo13080949", "article-title": "Metabolism study of anamorelin, a GHSR1a receptor agonist potentially misused in sport, with human hepatocytes and LC-HRMS/MS", "author": "Gameli", "doi-asserted-by": "publisher", "journal-title": "Metabolites.", "key": "B31", "volume": "13", "year": "2023" }, { "DOI": "10.3390/nu15183899", "article-title": "The role of lipids in the regulation of immune responses", "author": "Garcia", "doi-asserted-by": "publisher", "first-page": "3899", "journal-title": "Nutrients.", "key": "B32", "volume": "15", "year": "2023" }, { "DOI": "10.1146/annurev-virology-091919-102416", "article-title": "Viruses and metabolism: the effects of viral infections and viral insulins on host metabolism", "author": "Girdhar", "doi-asserted-by": "publisher", "first-page": "373", "journal-title": "Annu. Rev. Virol.", "key": "B33", "volume": "8", "year": "2021" }, { "DOI": "10.1111/imr.13019", "article-title": "RNA regulatory mechanisms that control antiviral innate immunity", "author": "Gokhale", "doi-asserted-by": "publisher", "first-page": "77", "journal-title": "Immunol. Rev.", "key": "B34", "volume": "304", "year": "2021" }, { "DOI": "10.1038/s41392-021-00809-8", "article-title": "The glycosylation in SARS-CoV-2 and its receptor ACE2", "author": "Gong", "doi-asserted-by": "publisher", "first-page": "396", "journal-title": "Signal Transduct Target Ther.", "key": "B35", "volume": "6", "year": "2021" }, { "DOI": "10.1101/2025.07.16.25331404", "article-title": "Extracellular vesicle miRNA signatures in pediatric onset-multiple sclerosis and obesity-driven immune and metabolic dysregulation", "author": "Hade", "doi-asserted-by": "publisher", "journal-title": "medRxiv", "key": "B36", "volume": "16", "year": "2025" }, { "DOI": "10.1186/s12964-025-02368-9", "article-title": "Immuno-metabolic diseases and therapeutics: molecular mechanisms via inflammasome signaling", "author": "Han", "doi-asserted-by": "publisher", "first-page": "373", "journal-title": "Cell Commun. Signal.", "key": "B37", "volume": "23", "year": "2025" }, { "DOI": "10.1038/nrm2329", "article-title": "Principles of bioactive lipid signalling: lessons from sphingolipids", "author": "Hannun", "doi-asserted-by": "publisher", "first-page": "139", "journal-title": "Nat. Rev. Mol. Cell Biol.", "key": "B38", "volume": "9", "year": "2008" }, { "DOI": "10.3390/v14010003", "article-title": "Untargeted lipidomics of vesicular stomatitis virus-infected cells and viral particles", "author": "Havranek", "doi-asserted-by": "publisher", "journal-title": "Viruses.", "key": "B39", "volume": "14", "year": "2021" }, { "DOI": "10.1128/mbio.02297-22", "article-title": "Grass carp reovirus induces formation of lipid droplets as sites for its replication and assembly", "author": "He", "doi-asserted-by": "publisher", "first-page": "e0229722", "journal-title": "mBio.", "key": "B40", "volume": "13", "year": "2022" }, { "DOI": "10.1016/j.jnutbio.2015.11.002", "article-title": "Role of lipids in the metabolism and activation of immune cells", "author": "Hubler", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "J. Nutr. Biochem.", "key": "B41", "volume": "34", "year": "2016" }, { "DOI": "10.1007/5584_2022_759", "article-title": "Rafting on the plasma membrane: lipid rafts in signaling and disease", "author": "Isik", "doi-asserted-by": "publisher", "first-page": "87", "journal-title": "Adv. Exp. Med. Biol.", "key": "B42", "volume": "1436", "year": "2023" }, { "DOI": "10.1507/endocrj.EJ25-0180", "article-title": "Lipid metabolic reprogramming in immune regulation and chronic inflammatory diseases", "author": "Ito", "doi-asserted-by": "publisher", "first-page": "979", "journal-title": "Endocr. J.", "key": "B43", "volume": "72", "year": "2025" }, { "DOI": "10.1615/critreveukaryotgeneexpr.v13.i1.50", "article-title": "Mechanisms mediating oxalate-induced alterations in renal cell functions", "author": "Jonassen", "doi-asserted-by": "publisher", "first-page": "55", "journal-title": "Crit. Rev. Eukaryot Gene Expr.", "key": "B44", "volume": "13", "year": "2003" }, { "DOI": "10.3389/fimmu.2020.572677", "article-title": "HIV-1 infection and glucose metabolism reprogramming of T cells: another approach toward functional cure and reservoir eradication", "author": "Kang", "doi-asserted-by": "publisher", "journal-title": "Front. Immunol.", "key": "B45", "volume": "11", "year": "2020" }, { "DOI": "10.1073/pnas.0409834102", "article-title": "Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids", "author": "Kapadia", "doi-asserted-by": "publisher", "first-page": "2561", "journal-title": "Proc. Natl. Acad. Sci. U S A.", "key": "B46", "volume": "102", "year": "2005" }, { "DOI": "10.1186/s11658-020-00211-2", "article-title": "Metabolic host response and therapeutic approaches to influenza infection", "author": "Keshavarz", "doi-asserted-by": "publisher", "first-page": "15", "journal-title": "Cell Mol. Biol. Lett.", "key": "B47", "volume": "25", "year": "2020" }, { "DOI": "10.1016/j.drudis.2022.05.003", "article-title": "Key regulatory miRNAs in lipid homeostasis: Implications for cardiometabolic diseases and development of novel therapeutics", "author": "Khan", "doi-asserted-by": "publisher", "first-page": "2170", "journal-title": "Drug Discov. Today", "key": "B48", "volume": "27", "year": "2022" }, { "DOI": "10.1007/978-981-15-0602-4_17", "article-title": "Autophagy and lipid metabolism", "author": "Khawar", "doi-asserted-by": "publisher", "first-page": "359", "journal-title": "Adv. Exp. Med. Biol.", "key": "B49", "volume": "1206", "year": "2019" }, { "DOI": "10.3390/v13102068", "article-title": "Metabolic modifications by common respiratory viruses and their potential as new antiviral targets", "author": "Kleinehr", "doi-asserted-by": "publisher", "journal-title": "Viruses.", "key": "B50", "volume": "13", "year": "2021" }, { "DOI": "10.1016/j.amjcard.2020.08.004", "article-title": "Meta-analysis of effect of statins in patients with COVID-19", "author": "Kow", "doi-asserted-by": "publisher", "first-page": "153", "journal-title": "Am. J. Cardiol.", "key": "B51", "volume": "134", "year": "2020" }, { "DOI": "10.1371/journal.ppat.1006635", "article-title": "Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication", "author": "Kuss-Duerkop", "doi-asserted-by": "publisher", "first-page": "e1006635", "journal-title": "PloS Pathog.", "key": "B52", "volume": "13", "year": "2017" }, { "DOI": "10.3389/fimmu.2023.1228811", "article-title": "Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets", "author": "Li", "doi-asserted-by": "publisher", "journal-title": "Front. Immunol.", "key": "B53", "volume": "14", "year": "2023" }, { "DOI": "10.1016/j.immuni.2012.11.005", "article-title": "Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol", "author": "Liu", "doi-asserted-by": "publisher", "first-page": "92", "journal-title": "Immunity.", "key": "B54", "volume": "38", "year": "2013" }, { "DOI": "10.1128/jvi.00364-23", "article-title": "The small GTPase rab14 regulates the trafficking of ceramide from endoplasmic reticulum to golgi apparatus and facilitates classical swine fever virus assembly", "author": "Liu", "doi-asserted-by": "publisher", "first-page": "e0036423", "journal-title": "J. Virol.", "key": "B55", "volume": "97", "year": "2023" }, { "DOI": "10.3390/ijms252313207", "article-title": "Diacylglycerol kinases and its role in lipid metabolism and related diseases", "author": "Liu", "doi-asserted-by": "publisher", "journal-title": "Int. J. Mol. Sci.", "key": "B56", "volume": "25", "year": "2024" }, { "article-title": "Lipid metabolism and carcinogenesis, cancer development", "author": "Long", "first-page": "778", "journal-title": "Am. J. Cancer Res.", "key": "B57", "volume": "8", "year": "2018" }, { "DOI": "10.1016/j.ijbiomac.2024.136720", "article-title": "Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis", "author": "Ma", "doi-asserted-by": "publisher", "journal-title": "Int. J. Biol. Macromol", "key": "B58", "volume": "282", "year": "2024" }, { "DOI": "10.1128/JVI.02061-14", "article-title": "The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis", "author": "Martín-Acebes", "doi-asserted-by": "publisher", "first-page": "12041", "journal-title": "J. Virol.", "key": "B59", "volume": "88", "year": "2014" }, { "DOI": "10.1155/2008/134059", "article-title": "PPARs mediate lipid signaling in inflammation and cancer", "author": "Michalik", "doi-asserted-by": "publisher", "journal-title": "PPAR Res.", "key": "B60", "year": "2008" }, { "DOI": "10.1016/j.chemphyslip.2004.09.005", "article-title": "A 2H solid-state NMR spectroscopic investigation of biomimetic bicelles containing cholesterol and polyunsaturated phosphatidylcholine", "author": "Minto", "doi-asserted-by": "publisher", "first-page": "55", "journal-title": "Chem. Phys. Lipids.", "key": "B61", "volume": "132", "year": "2004" }, { "DOI": "10.3390/nu11061239", "article-title": "Towards a food pharmacy: immunologic modulation through diet", "author": "Molendijk", "doi-asserted-by": "publisher", "journal-title": "Nutrients.", "key": "B62", "volume": "11", "year": "2019" }, { "DOI": "10.1016/j.mam.2024.101279", "article-title": "NRF2-mediated regulation of lipid pathways in viral infection", "author": "Muzammil", "doi-asserted-by": "publisher", "journal-title": "Mol. Aspects Med.", "key": "B63", "volume": "97", "year": "2023" }, { "DOI": "10.1038/nri.2016.70", "article-title": "A guide to immunometabolism for immunologists", "author": "O’Neill", "doi-asserted-by": "publisher", "first-page": "553", "journal-title": "Nat. Rev. Immunol.", "key": "B64", "volume": "16", "year": "2016" }, { "DOI": "10.1016/S0070-2161(08)60137-9", "article-title": "Chapter 9 fusion of viral envelopes with cellular membranes", "author": "Ohnishi", "doi-asserted-by": "publisher", "first-page": "257", "journal-title": "Curr. Top. Membr Transp", "key": "B65", "volume": "32", "year": "2008" }, { "DOI": "10.1128/JVI.00015-16", "article-title": "Identification of the fusion peptide-containing region in betacoronavirus spike glycoproteins", "author": "Ou", "doi-asserted-by": "publisher", "first-page": "5586", "journal-title": "J. Virol.", "key": "B66", "volume": "90", "year": "2016" }, { "DOI": "10.3389/fonc.2024.1435480", "article-title": "Lipids in the tumor microenvironment: immune modulation and metastasis", "author": "Pascual", "doi-asserted-by": "publisher", "journal-title": "Front. Oncol.", "key": "B67", "volume": "14", "year": "2024" }, { "DOI": "10.1186/s12916-023-02874-y", "article-title": "Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials", "author": "Patikorn", "doi-asserted-by": "publisher", "first-page": "196", "journal-title": "BMC Med.", "key": "B68", "volume": "21", "year": "2023" }, { "DOI": "10.1016/0014-5793(91)80220-w", "article-title": "Cerulenin, an inhibitor of lipid synthesis, blocks vesicular stomatitis virus RNA replication", "author": "Pérez", "doi-asserted-by": "publisher", "first-page": "129", "journal-title": "FEBS Lett.", "key": "B69", "volume": "280", "year": "1991" }, { "DOI": "10.1002/jmv.28967", "article-title": "The interplay between lipid droplets and virus infection", "author": "Qu", "doi-asserted-by": "publisher", "first-page": "e28967", "journal-title": "J. Med. Virol.", "key": "B70", "volume": "95", "year": "2023" }, { "DOI": "10.1097/MOL.0000000000000883", "article-title": "Lipid metabolism", "author": "Raal", "doi-asserted-by": "publisher", "first-page": "93", "journal-title": "Curr. Opin. Lipidol.", "key": "B71", "volume": "34", "year": "2023" }, { "DOI": "10.1016/j.isci.2025.113750", "article-title": "Unraveling virus-host interactions: Current advances in viral lipidomics", "author": "Requena", "doi-asserted-by": "publisher", "journal-title": "iScience.", "key": "B72", "volume": "28", "year": "2025" }, { "DOI": "10.1101/2020.09.11.294363", "article-title": "Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model", "author": "Ryu", "doi-asserted-by": "publisher", "journal-title": "bioRxiv", "key": "B73", "volume": "11", "year": "2020" }, { "DOI": "10.1074/jbc.274.4.2038", "article-title": "Influenza viruses select ordered lipid domains during budding from the plasma membrane", "author": "Scheiffele", "doi-asserted-by": "publisher", "first-page": "2038", "journal-title": "J. Biol. Chem.", "key": "B74", "volume": "274", "year": "1999" }, { "DOI": "10.1007/s11154-019-09512-0", "article-title": "Dietary lipids, gut microbiota and lipid metabolism", "author": "Schoeler", "doi-asserted-by": "publisher", "first-page": "461", "journal-title": "Rev. Endocr. Metab. Disord.", "key": "B75", "volume": "20", "year": "2019" }, { "DOI": "10.1126/sciadv.adj4198", "article-title": "Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release", "author": "Shiota", "doi-asserted-by": "publisher", "first-page": "eadj4198", "journal-title": "Sci. Adv.", "key": "B76", "volume": "9", "year": "2023" }, { "DOI": "10.1093/jleuko/qiae170", "article-title": "Unlocking secrets: lipid metabolism and lipid droplet crucial roles in SARS-CoV-2 infection and the immune response", "author": "Soares", "doi-asserted-by": "publisher", "first-page": "1254", "journal-title": "J. Leukoc. Biol.", "key": "B77", "volume": "116", "year": "2024" }, { "DOI": "10.1016/j.ceb.2017.02.005", "article-title": "Viral rewiring of cellular lipid metabolism to create membranous replication compartments", "author": "Strating", "doi-asserted-by": "publisher", "first-page": "24", "journal-title": "Curr. Opin. Cell Biol.", "key": "B78", "volume": "47", "year": "2017" }, { "DOI": "10.1248/yakushi.16-00239-2", "article-title": "Immunological regulation by bioactive lipids", "author": "Taketomi", "doi-asserted-by": "publisher", "first-page": "503", "journal-title": "Yakugaku Zasshi.", "key": "B79", "volume": "137", "year": "2017" }, { "DOI": "10.1186/s12944-025-02642-2", "article-title": "Ceramide signaling in immunity: a molecular perspective", "author": "Thakkar", "doi-asserted-by": "publisher", "first-page": "225", "journal-title": "Lipids Health Dis.", "key": "B80", "volume": "24", "year": "2025" }, { "DOI": "10.1016/j.jlr.2021.100129", "article-title": "The roles of lipids in SARS-CoV-2 viral replication and the host immune response", "author": "Theken", "doi-asserted-by": "publisher", "journal-title": "J. Lipid Res.", "key": "B81", "volume": "62", "year": "2021" }, { "DOI": "10.1038/s41392-021-00726-w", "article-title": "HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19", "author": "Tian", "doi-asserted-by": "publisher", "first-page": "308", "journal-title": "Signal Transduct Target Ther.", "key": "B82", "volume": "6", "year": "2021" }, { "DOI": "10.1111/j.1365-2362.2008.02022.x", "article-title": "Nuclear receptors, transcription factors linking lipid metabolism and immunity: the case of peroxisome proliferator-activated receptor gamma", "author": "Varga", "doi-asserted-by": "publisher", "first-page": "695", "journal-title": "Eur. J. Clin. Invest.", "key": "B83", "volume": "38", "year": "2008" }, { "DOI": "10.1016/j.antiviral.2015.10.013", "article-title": "Targeting host lipid synthesis and metabolism to inhibit dengue and hepatitis C viruses", "author": "Villareal", "doi-asserted-by": "publisher", "first-page": "110", "journal-title": "Antiviral Res.", "key": "B84", "volume": "124", "year": "2015" }, { "DOI": "10.1371/journal.ppat.1003302", "article-title": "Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein", "author": "Vogt", "doi-asserted-by": "publisher", "first-page": "e1003302", "journal-title": "PloS Pathog.", "key": "B85", "volume": "9", "year": "2013" }, { "article-title": "Leukotrieny--mediatory zapalenia [Leukotrienes as inflammation mediators", "author": "Woszczek", "first-page": "593", "journal-title": "Postepy Hig. Med. Dosw.", "key": "B86", "volume": "57", "year": "2003" }, { "DOI": "10.1371/journal.pntd.0011923", "article-title": "Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection", "author": "Xu", "doi-asserted-by": "publisher", "journal-title": "PloS Negl. Trop. Dis.", "key": "B87", "volume": "18", "year": "2024" }, { "DOI": "10.3390/v11010073", "article-title": "Characterization of the lipidomic profile of human coronavirus-infected cells: implications for lipid metabolism remodeling upon coronavirus replication", "author": "Yan", "doi-asserted-by": "publisher", "journal-title": "Viruses.", "key": "B88", "volume": "11", "year": "2019" }, { "DOI": "10.1016/j.intimp.2024.113223", "article-title": "Stilbene glycosides alleviate atherosclerosis partly by promoting lipophagy of dendritic cells", "author": "Yang", "doi-asserted-by": "publisher", "journal-title": "Int. Immunopharmacol", "key": "B89", "volume": "143", "year": "2024" }, { "DOI": "10.1128/JVI.06467-11", "article-title": "Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1", "author": "Yu", "doi-asserted-by": "publisher", "first-page": "2942", "journal-title": "J. Virol.", "key": "B90", "volume": "86", "year": "2012" }, { "DOI": "10.1038/s41467-018-08015-x", "article-title": "SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target", "author": "Yuan", "doi-asserted-by": "publisher", "first-page": "120", "journal-title": "Nat. Commun.", "key": "B91", "volume": "10", "year": "2019" }, { "DOI": "10.1016/j.isci.2021.103469", "article-title": "Fluvastatin mitigates SARS-CoV-2 infection in human lung cells", "author": "Zapatero-Belinchón", "doi-asserted-by": "publisher", "journal-title": "iScience.", "key": "B92", "volume": "24", "year": "2021" }, { "DOI": "10.1016/j.plipres.2006.01.002", "article-title": "Lipid rafts & Co.: an integrated model of membrane organization in T cell activation", "author": "Zeyda", "doi-asserted-by": "publisher", "first-page": "275", "journal-title": "Prog. Lipid Res.", "key": "B93", "volume": "46", "year": "2007" }, { "DOI": "10.3389/fmicb.2017.02286", "article-title": "Modulation of lipid droplet metabolism-A potential target for therapeutic intervention in flaviviridae infections", "author": "Zhang", "doi-asserted-by": "publisher", "journal-title": "Front. Microbiol.", "key": "B94", "volume": "8", "year": "2017" }, { "DOI": "10.1016/j.cmet.2020.06.015", "article-title": "In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19", "author": "Zhang", "doi-asserted-by": "publisher", "first-page": "176", "journal-title": "Cell Metab.", "key": "B95", "volume": "32", "year": "2020" }, { "DOI": "10.1038/s41598-023-35290-6", "article-title": "Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism", "author": "Zhu", "doi-asserted-by": "publisher", "first-page": "8078", "journal-title": "Sci. Rep.", "key": "B96", "volume": "13", "year": "2023" }, { "DOI": "10.1016/j.mehy.2023.111020", "article-title": "Adipocytes in obesity: A perfect reservoir for SARS-CoV-2", "author": "Zhu", "doi-asserted-by": "publisher", "journal-title": "Med. Hypotheses", "key": "B97", "volume": "171", "year": "2023" } ], "reference-count": 97, "references-count": 97, "relation": {}, "resource": { "primary": { "URL": "https://www.frontiersin.org/articles/10.3389/fcimb.2026.1765502/full" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Lipid metabolism, viral infection, and antiviral immunity: a new host-pathogen interface", "type": "journal-article", "update-policy": "https://doi.org/10.3389/crossmark-policy", "volume": "16" }