Summary of COVID-19 brequinar studies

1. Powers et al., The CRISIS2 Study: A Phase 2, Randomized, Double Blind, Placebo-controlled, Multi-center Study Assessing the Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Out-patient Adults With SARS-CoV-2

115 patient brequinar early treatment RCT: 205% higher hospitalization (p=0.49) and 34% worse viral clearance.
RCT 115 outpatients in the USA, showing no significant differences with brequinar treatment.
Apr 2021, NCT04575038, https://clinicaltrials.gov/study/NCT04575038, https://c19p.org/powers2