Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection
et al., Redox Biology, doi:10.1016/j.redox.2026.104273, Jun 2026
Cross-sectional study of 750 adults assessed on average 21.9 months after PCR-verified SARS-CoV-2 infection, showing that the combination of low serum selenium (<70 μg/L) or low SELENOP (<4.1 mg/L) with SELENOP autoantibodies (SELENOP-aAb ≥3.0 BI) was associated with approximately 2-fold higher prevalence of persistent fatigue. Authors hypothesize that pro-inflammatory cytokines from SARS-CoV-2 infection reduce selenoprotein biosynthesis, potentially leading to misincorporation of amino acids at selenocysteine positions, generating neoantigens and subsequent SELENOP autoantibodies that impair selenium transport to extrahepatic tissues, ultimately disrupting thyroid hormone activation (T4 to T3 conversion) and causing fatigue.
Schmidt et al., 27 Jun 2026, Germany, peer-reviewed, mean age 48.3, 12 authors, study period September 2021 - May 2023.
Contact: boerge.schmidt@uk-essen.de, lutz.schomburg@charite.de.
Abstract:
Contents lists available at ScienceDirect
Redox Biology
journal homepage: www.elsevier.com/locate/redox
Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection
B ¨ orge Schmidt a,*,1 , Sabrina Asaad b,1 , Laven Mavarani a , Andreas Stang a Thilo S. Chillon b , Waldemar B. Minich b , Kostja Renko b , Thorsten Brenner Lara Maria Sch ¨ oler d,e , Ulf Dittmer d , Mirko Trilling d,e,1 , Lutz Schomburg
- a Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- b Institute for Experimental Endocrinology, Charit ´ e - Universit ¨ atsmedizin-Berlin, Berlin, Germany
- c Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- d Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- e Institute for the Research on HIV and AIDS-associated Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
A B S T R A C T
Background: Cytokines found during post-acute sequelae after COVID-19 are known to reduce selenoprotein biosynthesis, raising the question whether low selenium, impaired selenoprotein P (SELENOP) production, and autoantibodies to SELENOP (SELENOP-aAb) are associated with persistent fatigue after SARS-CoV-2 infection. Methods: Persistent symptoms and selenium determinants were assessed on average 21.9 months after a PCR-verified SARS-CoV-2 infection in a cross-sectional population-based study (n = 750 adults, 54.1% female). Study participants were categorized based on the presence of low selenium levels ( < 70 μ g/L), low SELENOP levels ( < 4.1 mg/L), and SELENOP-aAb positivity ( ≥ 3.0 BI). Regression models were fitted to assess associations between selenium determinants and persistent fatigue, adjusted for potential confounders.
Findings: Persistent fatigue was self-reported by 23.1% (n = 173) of participants. Low serum selenium was measured in 63.7% (n = 478), low SELENOP in 89.6% (n = 672), and elevated SELENOP-aAb in 3.9% (n = 29). A combination of low selenium and elevated SELENOP-aAb was found in 1.9% (n = 14) participants, a combination of low SELENOP and SELENOP-aAb in 3.2% (n = 24). Individually, all three selenium-related determinants showed no strong indication for an association with persistent fatigue. However, the combination of selenium deficiency and SELENOP-aAb positivity showed a prevalence ratio of 2.16 (95%-CI: 1.134.11), and the combination of SELENOP deficiency and SELENOP-aAb positivity a prevalence ratio of 2.15 (95% Cl: 1.01; 4.60) compared to the reference group. Interpretation: The study indicates that in a fraction of COVID-19 affected participants low selenium/SELENOP levels in combination with SELENOP-specific autoantibodies are associated with a two times higher prevalence of persistent fatigue after SARS-CoV-2 infection.
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"DOI": "10.7554/eLife.86015",
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"DOI": "10.1093/infdis/jiac136",
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"author": "Chen",
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},
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},
{
"DOI": "10.1152/physrev.00039.2013",
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"volume": "94",
"year": "2014"
},
{
"DOI": "10.1146/annurev-nutr-071714-034250",
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"year": "2015"
},
{
"DOI": "10.1016/j.freeradbiomed.2022.08.022",
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"author": "Schomburg",
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},
{
"DOI": "10.1007/s10787-025-02033-0",
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"doi-asserted-by": "crossref",
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"issue": "6",
"journal-title": "Cell Rep. Med.",
"key": "10.1016/j.redox.2026.104273_bib18",
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},
{
"DOI": "10.1038/s41467-023-40012-7",
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"author": "Woodruff",
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"first-page": "4201",
"issue": "1",
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},
{
"DOI": "10.1038/s41590-023-01724-6",
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"author": "Yin",
"doi-asserted-by": "crossref",
"first-page": "218",
"issue": "2",
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"volume": "25",
"year": "2024"
},
{
"DOI": "10.1126/sciadv.adi9379",
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"author": "Krishna",
"doi-asserted-by": "crossref",
"issue": "8",
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},
{
"DOI": "10.1096/fj.08-119370",
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"author": "Renko",
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"issue": "6",
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"volume": "23",
"year": "2009"
},
{
"DOI": "10.3389/fimmu.2020.595282",
"article-title": "Hepatic-Specific decrease in the expression of selenoenzymes and factors essential for selenium processing after endotoxemia",
"author": "Sherlock",
"doi-asserted-by": "crossref",
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"key": "10.1016/j.redox.2026.104273_bib23",
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{
"DOI": "10.1039/C5MT00211G",
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"author": "Martitz",
"doi-asserted-by": "crossref",
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"DOI": "10.1074/jbc.272.46.29364",
"article-title": "Cloning and characterization of the human selenoprotein P promoter. Response of selenoprotein P expression to cytokines in liver cells",
"author": "Dreher",
"doi-asserted-by": "crossref",
"first-page": "29364",
"issue": "46",
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"volume": "272",
"year": "1997"
},
{
"DOI": "10.3389/fimmu.2022.1022673",
"article-title": "Association of COVID-19 mortality with serum selenium, zinc and copper: six observational studies across Europe",
"author": "Demircan",
"doi-asserted-by": "crossref",
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"key": "10.1016/j.redox.2026.104273_bib26",
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{
"DOI": "10.1073/pnas.1009947107",
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"author": "Xu",
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"first-page": "21430",
"issue": "50",
"journal-title": "Proc. Natl. Acad. Sci. U. S. A.",
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"volume": "107",
"year": "2010"
},
{
"DOI": "10.1038/s41598-017-04586-9",
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"author": "Renko",
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"first-page": "4391",
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"year": "2017"
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{
"DOI": "10.1126/science.abg3875",
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"author": "Hilal",
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"first-page": "1338",
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"DOI": "10.1371/journal.pone.0140353",
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"DOI": "10.1074/jbc.M112.446666",
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"DOI": "10.3390/ijms222313088",
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"DOI": "10.1371/journal.pone.0337848",
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"DOI": "10.3389/fendo.2018.00097",
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"author": "Ruiz-Núñez",
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{
"DOI": "10.1016/j.freeradbiomed.2022.01.024",
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"author": "Tawfik",
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"first-page": "197",
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"DOI": "10.1016/S0140-6736(24)01614-3",
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"first-page": "1347",
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"DOI": "10.1159/000469709",
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"author": "Carlé",
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"year": "2017"
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"DOI": "10.1038/ng1654",
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"first-page": "1247",
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"volume": "37",
"year": "2005"
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{
"DOI": "10.3389/fimmu.2021.645013",
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"author": "Tang",
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"author": "Wu",
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"DOI": "10.1210/clinem/dgac410",
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"author": "de Man",
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"first-page": "33",
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"volume": "49",
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"DOI": "10.1016/j.redox.2022.102346",
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"DOI": "10.1016/j.joca.2008.06.011",
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