Comprehensive and translational pathobiology of COVID-19 based on cellular and molecular techniques
Ali Akbar Samadani, Sogand Vahidi, Kosar Babaei, Seyedeh Elham Norollahi, Kourosh Delpasand, Elaheh Asghari Gharakhyli
Practical Laboratory Medicine, doi:10.1016/j.plabm.2025.e00497
The biggest health issue in the world right now is the COVID-19 pandemic. This outbreak has caused a lot more people to be hospitalized for pneumonia and serious health problems, leading to many deaths. This report talks about many studies that showed the causes and how common COVID-19 is, as well as how to diagnose it in clinics and labs, and how to prevent and control it. These studies are very important and directly related to COVID-19 to help manage the current public emergency. Many parts of this dangerous disease, like how it spreads, how to diagnose it, how it infects people, and how to treat it, are still not well understood. It's important that to prevent, diagnose, and treat COVID-19 well, we need research at the molecular and clinical levels, along with public health measures and medical treatments. Clearly, new treatments like mesenchymal stem cell therapy have shown great promise in this area. Here, we will talk about and show the advanced lab methods used to understand how COVID-19 spreads, how it is diagnosed, and how it can be treated.
Authors' contributions AAS designed the project, wrote the paper, and edited and reviewed the final version of the manuscript. SEN, KB, KD, and SV contributed to many different parts, including data collection, writing the manuscript, and drawing the figures. EAGh accompanied in some sections of the article. All the authors read and confirmed the final version of the paper. NSP polyprotein binds at numerous different locations
NSP7 A component of the replication-transcription complex, and builds complex with NSP8 and 12
NSP8 A component of replication-transcription complex that includes a heterodimer with NSP8 and 12.
NSP2 Suppression of the host translation mechanism as well as the innate immune system linkes to PHBs 1 and 2 and is thought to play a function in the triggering of apoptosis.
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