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Treatment with Minocycline and Kampo Medicine (Kami-Kihi-To and Saiko-Keishi-To) for COVID-19 and Long COVID

Ohe, M., Preprints.org, 10.20944/preprints202507.1139.v1 , Jul 2025
https://c19early.org/ohe.html
Review of minocycline and traditional Japanese Kampo formulas as potential treatments for COVID-19 and long COVID. Authors explain that lipophilic tetracyclines such as minocycline chelate zinc in host matrix metalloproteinases, inhibit the SARS-CoV-2 main protease and spike-ACE2 interaction, and attenuate microglial-driven neuroinflammation, citing clinical reports where minocycline or doxycycline improved viral clearance and symptoms.
Ohe et al., 15 Jul 2025, preprint, 1 author.
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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