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Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial

Evering et al., eClinicalMedicine, doi:10.1016/j.eclinm.2024.102787, ACTIV-2/A5401, NCT04518410
Aug 2024  
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Mortality 91% Improvement Relative Risk PASC -20% Hospitalization 61% Death/hospitalization 67% Amubarvimab/r..  ACTIV-2/A5401  EARLY TREATMENT  DB RCT Is early treatment with amubarvimab beneficial for COVID-19? Double-blind RCT 780 patients in multiple countries (Jan - Jul 2021) Lower mortality (p=0.006) and hospitalization (p=0.00082) c19early.org Evering et al., eClinicalMedicine, Aug 2024 Favorsamubarvimab Favorscontrol 0 0.5 1 1.5 2+
RCT 780 high-risk non-hospitalized COVID-19 patients showing significantly lower risk of hospitalization or death through 36 weeks, but no significant difference in long COVID with amubarvimab/romlusevimab treatment compared to placebo.
Efficacy is variant dependent.
risk of death, 90.9% lower, RR 0.09, p = 0.006, treatment 1 of 390 (0.3%), control 11 of 390 (2.8%), NNT 39, day 252.
risk of PASC, 20.5% higher, RR 1.20, p = 0.39, treatment 53 of 390 (13.6%), control 44 of 390 (11.3%), day 252.
risk of hospitalization, 61.0% lower, RR 0.39, p < 0.001, treatment 16 of 390 (4.1%), control 41 of 390 (10.5%), NNT 16, day 252.
risk of death/hospitalization, 67.3% lower, RR 0.33, p < 0.001, treatment 17 of 390 (4.4%), control 52 of 390 (13.3%), NNT 11, day 252.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Evering et al., 16 Aug 2024, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, median age 49.0, 14 authors, study period January 2021 - July 2021, trial NCT04518410 (history) (ACTIV-2/A5401). Contact: evering@med.cornell.edu.
This PaperAmubarv../r..All
Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial
Teresa H Evering, Carlee Moser, Nikolaus Jilg, Justin Ritz, David A Wohl, Jonathan Z Li, David Margolis, Arzhang Cyrus Javan, Joseph J Eron, Judith S Currier, Eric S Daar, Davey M Smith, Michael D Hughes, Kara W Chew, Kara W Chew, David (davey) Smith, Eric S Daar, David A Wohl, Judith S Currier, Joseph J Eron, Arzhang Cyrus Javan, Michael D Hughes, Carlee Moser, Mark Giganti, Justin Ritz, Lara Hosey, Jhoanna Roa, Nilam Patel, Kelly Colsh, Irene Rwakazina, Justine Beck, Scott Sieg, Jonathan Z Li, Courtney Fletcher, William Fischer, Teresa H Evering, Rachel Bender Ignacio, Sandra Cardoso, Katya Corado, Prasanna Jagannathan, Nikolaus Jilg, Alan Perelson, Sandy Pillay, Cynthia Riviere, Upinder Singh, Babafemi Taiwo, Joan Gottesman, Matthew Newell, Susan Pedersen, Joan Dragavon, Cheryl Jennings, Brian Greenfelder, William Murtaugh, Jan Kosmyna, Morgan Gapara, Akbar Shahkolahi, David Margolis, Verónica Lacal, Diego Salusso, Sebastian Nuñez, Marcelo Rodrigo Rodriguez, Luciana Laborde, Marcelo Papasidero, Luis Wehbe, Mariana Gonzalez, Felicitas Fernandez Voena, Tomas Alvarez, Amaru Lopez, Virginia Huhn, Ulises D'andrea Nores, Pablo Dieser, Fernando Bordese, Marisa Mussi, Rodrigo De Carvalho Santana, Adriana Aparecida Tiraboschi Bárbaro, Breno Santos, Rita De Cássia Alves Lira, Andre Luiz Machado Da Silva, Sandra Wagner Cardoso, Maria Pia Diniz Ribeiro, Nathália Soliva, Eduardo Vasconcellos, Jorge Eurico Ribeiro, Miriam Amaral Enéas, Jorge Pinto, Julia Fonseca De Morais Caporali, Flávia Gomes Faleiro Ferreira, Norma Erendira Rivera Martinez, Victor Casildo Bohorquez Lopez, Melchor Victor Frias, Krystle Fetalvero, Alyxzza Maranan, Jennifer Rosa, Thomas Coetzer, Maureen Mohata, Umesh Lalloo, Sandy Pillay, Penelope Madlala, Larisha Pillay-Ramaya, Jaclyn Ann Bennet, Noluthando Mwelase, Nokuphiwa Mbhele, Frederick Petrick, Leonard Joubert, Rose Mbali, Natasha Joseph, Mmatsie Manentsa, Eugene Van Der Walt, Mduduzi Sandile Lawrance Masilela, Zinhle Zwane, Tendai Chiperera, Lerato Mohapi, Suri Moonsamy, Usha Singh, Kirsten Mcharry, Elizma Snyman, Pieter Lennox, James Craig Innes, Oteng Letlape, Olebogeng Jonkane, William Brumskine, Tania Adonis, Ni Ni Sein, Modulakgotla Sebe, Yacoob Vahed, Nazreen Jeewa Hussen, Ismail Mitha, Vasundhara Cheekati, Purna Cheekati, Christie Lummus, Samuel Idarraga, Andrew Kim, David N Pham, Wei-Hsin Kao, Michael M Pfeffer, Miriam Batule Dominguez, Anju Malik, Anna Bryan, Melanie Arnold, Idania Fernandez, Cinzia Karpf, Aniuska Ruiz, David Taylor, Eric Folkens, Jennifer Manne, Sigal Yawetz, Cheryl Keenan, Emeka Eziri, Carl Fichtenbaum, Jenifer Baer, Sarah Trentman, Robert Call, Leroy Vaughan, Aaron Milstone, Jamie Alex Slandzicki, Jessica Wallan, Clinton Guillory, Nancy Andrews, Leslie Hughes, Teresa H Evering, Jonathan Berardi, Celine Arar, Randall Quinn, Jorge P Amaya, Marissa Gomez-Martinez, Luis Cantu, Monica Betancourt-Garcia, Nwora Lance Okeke, Charles M Burns, Fadi Haddad, Victoria Haddad, Augusto Focil, Griselda Rosas, Susana Moyano, Yaneicy Gonzalez Rojas, Ahmad Aswad, Yevgeniy Bukhman, Manish Jain, Eugene Bukhman, Humam Farah, Rebekah Mcclain, Eric S Daar, Sadia Shaik, Timothy Hatlen, Deepa Gotur, Joseph Surber, Jeffrey Kingsley, April Pixler, Alex Zopo, Jack Herman, Craig Herman, Ramon Leon, Boris Nikolov, Fernando Gonzalez Vergara, Ana I Gonzalez, Noemi Gonzalez, Michael Gelman, Olga Andriunas, Zarema Jagizarov, Jan Westerman, David Davis, Donna Sherer, Kelly Dooley, Becky Becker, Adaliah Wilkins, Jose Pérez, Eloy Roman, Heriberto Fernández, Bharat Mocherla, Kelly Beck, Valarie Maldonado, Jennifer Veltman, Rajesh Gandhi, Katrina Shea, Matthew Planchon, Laura Bogan Herpel, Kaushlendra K Tripathi, Donald C Day, John Pullman, Erin Williams-Leber, Misty Johnson, Michelle Hecker, Ann Avery, Keila Hoover, George W Monlux, Elizabeth Juneja, Arthur Wernick, Karelia Ruiz, Maureen Hernández, Yadilys Pérez, Babafemi O Taiwo, Claudia Hawkins, Baiba Berzins, Carlos Malvestutto, Heather Harber, Robyn Cicarella, Edwin Dejesus, Charlotte-Paige Rolle, Almena L Free, Sallie D Pulliam, Debra Weinstein, Rosa M Suarez, Ezequiel Socorro, Estefania Socorro, Gene Neytman, Jack Herman, Craig Herman, Raymond Easley, Mariam Aziz, Joan Swiatek
eClinicalMedicine, doi:10.1016/j.eclinm.2024.102787
Background It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitalization/death by 79%. This study assessed the impact of amubarvimab/romlusevimab on late outcomes, including Long COVID. Methods Non-hospitalized high-risk adults within 10 days of COVID-19 symptom onset enrolled in a randomized, double-blind, placebo-controlled phase 2/3 trial of amubarvimab/romlusevimab for COVID-19 treatment. Late symptoms, assessed using a participant-completed symptom diary, were a pre-specified exploratory endpoint. The primary outcome for this analysis was the composite of Long COVID by participant self-report (presence of COVID-19 symptoms as recorded in the diary at week 36) or hospitalization or death by week 36. Inverse probability weighting (IPW) was used to address incomplete outcome ascertainment, giving weighted risk ratios (wRR) comparing amubarvimab/romlusevimab to placebo. Findings Participants received amubarvimab/romlusevimab (n = 390) or placebo (n = 390) between January and July 2021. Median age was 49 years, 52% were female, 18% Black/African American, 49% Hispanic/Latino, and 9% COVID-19-vaccinated at entry. At week 36, 103 (13%) had incomplete outcome ascertainment, and 66 (17%) on amubarvimab/romlusevimab and 92 (24%) on placebo met the primary outcome (wRR = 0.70, 95% confidence interval (CI) 0.53-0.93). The difference was driven by fewer hospitalizations/deaths with amubarvimab/ romlusevimab (4%) than placebo (13%). Among 652 participants with available diary responses, 53 (16%) on amubarvimab/romlusevimab and 44 (14%) on placebo reported presence of Long COVID. Interpretation Amubarvimab/romlusevimab treatment, while highly effective in preventing hospitalizations/deaths, did not reduce risk of Long COVID. Additional interventions are needed to prevent Long COVID.
Appendix A. Supplementary data Supplementary data related to this article can be found at https://doi. org/10.1016/j.eclinm.2024.102787.
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