Summary of COVID-19 CK0802 studies
Hide extended summaries
RCT 45 critically ill COVID-19 ARDS patients showing no significant difference with allogeneic cord blood T-regulatory cells (Tregs). Patients were randomized to receive placebo, 100 million Tregs, or 300 million Tregs with three infusions over 7 days. While the 100 million cell dose group showed a higher probability of survival (not meeting the 99% threshold for significance), the 300 million cell group showed no benefit. Authors note that this may be due to baseline imbalances in the high-dose group.
Jun 2023, Blood Advances, https://ashpublications.org/bloodadvances/article/7/13/3075/495068/Randomized-double-blinded-placebo-controlled-trial, https://c19p.org/gladstone
1. Gladstone et al., Randomized, double-blinded, placebo-controlled trial of allogeneic cord blood T-regulatory cells for treatment of COVID-19 ARDS
30 patient CK0802 late treatment RCT: 8% higher mortality (p=0.91) and 27% higher combined mortality/intubation (p=0.42).RCT 45 critically ill COVID-19 ARDS patients showing no significant difference with allogeneic cord blood T-regulatory cells (Tregs). Patients were randomized to receive placebo, 100 million Tregs, or 300 million Tregs with three infusions over 7 days. While the 100 million cell dose group showed a higher probability of survival (not meeting the 99% threshold for significance), the 300 million cell group showed no benefit. Authors note that this may be due to baseline imbalances in the high-dose group.
Jun 2023, Blood Advances, https://ashpublications.org/bloodadvances/article/7/13/3075/495068/Randomized-double-blinded-placebo-controlled-trial, https://c19p.org/gladstone
Please send us corrections, updates, or comments.
c19early involves the extraction of 100,000+ datapoints from
thousands of papers. Community updates
help ensure high accuracy.
Treatments and other interventions are complementary.
All practical, effective, and safe
means should be used based on risk/benefit analysis.
No treatment or intervention is 100% available and effective for all current
and future variants.
We do not provide medical advice. Before taking any medication,
consult a qualified physician who can provide personalized advice and details
of risks and benefits based on your medical history and situation. IMA and WCH
provide treatment protocols.
Thanks for your feedback! Please search before submitting papers and note
that studies are listed under the date they were first available, which may be
the date of an earlier preprint.