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The association between B vitamins and the risk of COVID-19

Darand et al., British Journal of Nutrition, doi:10.1017/S0007114522003075
Nov 2022  
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Retrospective 9,189 adults showing no significant relationship between vitamin B9 intake and COVID-19 cases.
Darand et al., 9 Nov 2022, retrospective, Iran, peer-reviewed, 6 authors.
This PaperVitamin B9All
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This study was undertaken on 9189 adult participants of ' 'the Yazd Health Study (YaHS) and Taghzieh Mardom-e-Yazd (TAMIZ) study aged 20 to 69 years. ' 'Data on dietary intakes were obtained using a validated FFQ. Multivariable logistic ' 'regression analysis was used to evaluate the association between B vitamins and COVID-19. Our ' 'findings indicated that participants in the fourth quartile of vitamin ' 'B<jats:sub>5</jats:sub> intake compared with the first quartile had a protective effect ' 'against COVID-19 (OR: 0·53, 95 % CI 0·28, 0·99, <jats:italic>P</jats:italic>-trend = 0·02) ' 'after adjustment for all possible confounds in model 3. In addition, participants in the ' 'third quartile of vitamin B<jats:sub>12</jats:sub> intake compared with the first quartile ' '(OR: 0·63, 95 % CI 0·40, 0·98, <jats:italic>P</jats:italic>-trend = 0·11) had fewer odds of ' 'COVID-19 after full adjustments for confounders. Our findings indicated no significant ' 'relationship between dietary intake of vitamin B<jats:sub>1</jats:sub>, ' 'B<jats:sub>2</jats:sub>, B<jats:sub>3</jats:sub>, B<jats:sub>9</jats:sub> and B-complex and ' 'COVID-19. A higher intake of vitamin B<jats:sub>5</jats:sub> could reduce the odds of ' 'COVID-19 by 47 %, and a moderate intake of vitamin B<jats:sub>12</jats:sub> had a protective ' 'effect on COVID-19. Although our study has promising results, stronger clinical studies are ' 'needed.</jats:p>', 'DOI': '10.1017/s0007114522003075', 'type': 'journal-article', 'created': {'date-parts': [[2022, 11, 9]], 'date-time': '2022-11-09T05:42:33Z', 'timestamp': 1667972553000}, 'page': '1-9', 'update-policy': 'http://dx.doi.org/10.1017/policypage', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The association between B vitamins and the risk of COVID-19', 'prefix': '10.1017', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-2636-0963', 'authenticated-orcid': False, 'given': 'Mina', 'family': 'Darand', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-3023-1681', 'authenticated-orcid': False, 'given': 'Shirin', 'family': 'Hassanizadeh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fahime', 'family': 'Martami', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shamim', 'family': 'Shams', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6455-0747', 'authenticated-orcid': False, 'given': 'Masoud', 'family': 'Mirzaei', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-7482-2494', 'authenticated-orcid': False, 'given': 'Mahdieh', 'family': 'Hosseinzadeh', 'sequence': 'additional', 'affiliation': []}], 'member': '56', 'published-online': {'date-parts': [[2022, 11, 9]]}, 'reference': [ { 'key': 'S0007114522003075_ref54', 'doi-asserted-by': 'publisher', 'DOI': '10.30574/gscbps.2020.11.2.0114'}, { 'key': 'S0007114522003075_ref42', 'doi-asserted-by': 'publisher', 'DOI': '10.12669/pjms.36.COVID19-S4.2776'}, { 'key': 'S0007114522003075_ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41430-022-01149-8'}, { 'key': 'S0007114522003075_ref30', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cmi.2021.06.002'}, { 'key': 'S0007114522003075_ref33', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12113286'}, { 'key': 'S0007114522003075_ref48', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/978-3-030-16073-9_7'}, { 'key': 'S0007114522003075_ref19', 'first-page': 'v1', 'article-title': 'The role of folic acid in the management of respiratory disease caused ' 'by COVID-19', 'volume': '12034980', 'author': 'Sheybani', 'year': '2020', 'journal-title': 'Preprint'}, { 'key': 'S0007114522003075_ref35', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmjnph-2021-000250'}, { 'key': 'S0007114522003075_ref28', 'unstructured': '28. Committee IR (2005) Guidelines for Data Processing and Analysis of ' 'the International Physical Activity Questionnaire (IPAQ)-Short and Long ' 'Forms. http://wwwipaqkise/scoringpdf (accessed November 2005).'}, { 'key': 'S0007114522003075_ref11', 'volume-title': 'Vitamins in the Prevention of Human Diseases', 'author': 'Herrmann', 'year': '2011'}, { 'key': 'S0007114522003075_ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.35454/rncm.v4n1.187'}, { 'key': 'S0007114522003075_ref52', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.mehy.2020.110142'}, { 'key': 'S0007114522003075_ref49', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.6537'}, { 'key': 'S0007114522003075_ref29', 'first-page': '1073', 'article-title': 'The Iranian Version of International Physical Activity Questionnaire ' '(IPAQ) in Iran: content and construct validity, factor structure, ' 'internal consistency and stability', 'volume': '18', 'author': 'Moghaddam', 'year': '2012', 'journal-title': 'World Appl Sci J'}, { 'key': 'S0007114522003075_ref40', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.dsx.2020.07.001'}, { 'key': 'S0007114522003075_ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/978-1-60761-061-8'}, { 'key': 'S0007114522003075_ref53', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/jhn.12814'}, { 'key': 'S0007114522003075_ref51', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu13030812'}, { 'key': 'S0007114522003075_ref31', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12040988'}, { 'key': 'S0007114522003075_ref57', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.mehy.2016.07.007'}, { 'key': 'S0007114522003075_ref37', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMp2021264'}, { 'key': 'S0007114522003075_ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/metabo11090565'}, { 'key': 'S0007114522003075_ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.2471/BLT.20.267112'}, { 'key': 'S0007114522003075_ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.30574/gscbps.2020.11.3.0155'}, { 'key': 'S0007114522003075_ref27', 'first-page': '191', 'volume-title': 'Family Change in Iran: Religion, Revolution, and the State. 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