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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 89% Improvement Relative Risk Hospitalization 87% Hospitalization/ER 78% c19early.org/ev Novartis et al. Ensovibep for COVID-19 RCT EARLY TREATMENT Favors ensovibep Favors control
Novartis and Molecular Partners report positive topline data from Phase 2 study for ensovibep (MP0420), a DARPin antiviral therapeutic for COVID-19
Novartis Press Release (News)
10 Jan 2022    Source   PDF   Share   Tweet
EMPATHY Part A RCT with 407 patients, 301 treated with ensovibep, showing statistically significant viral load reduction (details not provided), and lower mortality and hospitalization. For discussion see [twitter.com].
risk of death, 89.0% lower, RR 0.11, p = 0.06, treatment 0 of 301 (0.0%), control 2 of 99 (2.0%), NNT 49, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 86.8% lower, RR 0.13, p = 0.01, treatment 2 of 301 (0.7%), control 5 of 99 (5.1%), NNT 23.
risk of hospitalization/ER, 78.1% lower, RR 0.22, p = 0.02, treatment 4 of 301 (1.3%), control 6 of 99 (6.1%), NNT 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Novartis et al., 10 Jan 2022, Randomized Controlled Trial, multiple countries, preprint, 1 author.
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