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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 89% Improvement Relative Risk Hospitalization 87% Hospitalization/ER 78% Ensovibep  Novartis et al.  EARLY TREATMENT  RCT Is early treatment with ensovibep beneficial for COVID-19? RCT 400 patients in multiple countries (May - November 2021) Lower hospitalization (p=0.012) and fewer hosp./ER visits (p=0.017) c19early.org Novartis, Press Release, January 2022 Favors ensovibep Favors control

Novartis and Molecular Partners report positive topline data from Phase 2 study for ensovibep (MP0420), a DARPin antiviral therapeutic for COVID-19

Novartis, Press Release
Jan 2022  
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EMPATHY Part A RCT with 407 patients, 301 treated with ensovibep, showing statistically significant viral load reduction (details not provided), and lower mortality and hospitalization. For discussion see twitter.com.
risk of death, 89.0% lower, RR 0.11, p = 0.06, treatment 0 of 301 (0.0%), control 2 of 99 (2.0%), NNT 49, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 86.8% lower, RR 0.13, p = 0.01, treatment 2 of 301 (0.7%), control 5 of 99 (5.1%), NNT 23.
risk of hospitalization/ER, 78.1% lower, RR 0.22, p = 0.02, treatment 4 of 301 (1.3%), control 6 of 99 (6.1%), NNT 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Novartis et al., 10 Jan 2022, Randomized Controlled Trial, multiple countries, preprint, 1 author, study period 10 May, 2021 - 18 November, 2021.
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