Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South Korea
Huh et al.,
Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South..,
medRxiv, doi:10.1101/2020.05.04.20089904 (Preprint)
Retrospective database analysis of 65,149 in South Korea, showing significantly lower cases with existing N-acetylcysteine treatment. The journal version of this paper does not present the N-acetylcysteine results.
risk of case, 26.2% lower, RR 0.74, p < 0.001, treatment 710 of 13,788 (5.1%), control 4,462 of 51,361 (8.7%), adjusted per study, odds ratio converted to relative risk, multivariable.
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Huh et al., 4 May 2020, retrospective, database analysis, South Korea, preprint, 10 authors.
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eastside1st@gmail.com.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.05.04.20089904; this version posted May 18, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Association of previous medications with the risk of COVID-19: a nationwide claimsbased study from South Korea
Running title: Use of previous medications and COVID-19 in Korea
Kyungmin Huh1¶, Wonjun Ji2¶, Minsun Kang3¶, Jinwook Hong3, Gi Hwan Bae3, Rugyeom
Lee3, Yewon Na3, Hyoseon Choi4, Seon Yeong Gong4, Jaehun Jung3, 4*
1
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center,
Sungkyunkwan University School of Medicine, Seoul, Korea
2
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of
Ulsan College of Medicine, Seoul, South Korea
3
Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon
University College of Medicine, Incheon, Korea
4
Department of Preventive Medicine, Gachon University College of Medicine, Incheon,
Korea
¶
KH, WJ, and MK contributed equally to this work.
Keywords: COVID-19, drug repositioning, treatment, prophylaxis
Running title: Use of various medications and COVID-19
Word count: 2,729
* Corresponding author:
1
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2020.05.04.20089904; this version posted May 18, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Jaehun Jung, MD, PhD
Department of Preventive Medicine, Gachon University College of Medicine
38-13, Dokjeom-ro 3, Incheon, Korea
E-mail: eastside1st@gmail.com
Abbreviations: ACE2, angiotensin-converting enzyme 2; ACEIs, ACE inhibitors; aOR,
adjusted odds ratio; ARBs, angiotensin receptor blockers; CCI, Charlson comorbidity index;
CI, confidence interval; COVID-19, coronavirus disease; CQ, chloroquine; HCQ,
hydroxychloroquine; HIRA, Health Insurance Review & Assessment Service; ICD-10,
International Classification of Diseases and Related Health Problems, 10th edition; OR, odds
ratio; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
2
medRxiv preprint doi: https://doi.org/10.1101/2020.05.04.20089904; this version posted May 18, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Abstract
Background. Identifying the association between medications taken prior to the infection of
coronavirus disease (COVID-19) might be useful during the current pandemic until a proven
treatment is developed. We aimed to determine whether the risk of developing COVID-19
was associated with the use of various drugs that may increase or decrease susceptibility to
severe acute respiratory syndrome coronavirus 2 infection and COVID-19.
Methods and Findings: A case-control study was performed using a nationwide claims
database of South Korea, where a large testing capacity has been available throughout..
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