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0 0.5 1 1.5 2+ Hospitalization 7% Improvement Relative Risk c19early.org/f Lenze et al. NCT04668950 STOP COVID 2 Fluvoxamine RCT EARLY Favors fluvoxamine Favors control
Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials
Lenze, E. (News), STOP COVID 2, NCT04668950 (history)
20 Aug 2021    Source   PDF   Share   Tweet
Presentation noting that STOP COVID 2 was terminated early for futility with only 30/551 cases of detioration and no significant treatment effect. The main results are not available yet, however partial results presented suggest that early treatment was more effective. Hospitalization results are from [medrxiv.org].
risk of hospitalization, 7.3% lower, RR 0.93, p = 1.00, treatment 11 of 272 (4.0%), control 12 of 275 (4.4%), NNT 313.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lenze et al., 20 Aug 2021, Double Blind Randomized Controlled Trial, USA, preprint, median age 47.0 (treatment) 48.0 (control), 1 author, average treatment delay 5.0 days, trial NCT04668950 (history) (STOP COVID 2).
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